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Literature summary for 3.4.22.27 extracted from

  • Beers, C.; Burich, A.; Kleijmeer, M.J.; Griffith, J.M.; Wong, P.; Rudensky, A.Y.
    Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo (2005), J. Immunol., 174, 1205-1212.
    View publication on PubMed
Search for more literature for 3.4.22.27

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Ii protein + H2O Mus musculus inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments Ii fragments
-
 ?
Ii protein + H2O Mus musculus C57BL/6 inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments Ii fragments
-
 ?
additional information Mus musculus cathepsin S in professional antigen-presenting cells, APC, controls MHC class II-mediated antigen presentation by epithelial cells in vivo, and plays a critical role in invariant chain degradation ?
-
 ?
additional information Mus musculus C57BL/6 cathepsin S in professional antigen-presenting cells, APC, controls MHC class II-mediated antigen presentation by epithelial cells in vivo, and plays a critical role in invariant chain degradation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell
-
 Mus musculus
-
bone marrow
-
 Mus musculus
-
dendritic cell
-
 Mus musculus
-
epithelial cell
-
 Mus musculus
-
intestine epithelial cell Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ii protein + H2O inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments Mus musculus Ii fragments
-
 ?
Ii protein + H2O Ii invariant chain Mus musculus Ii fragments
-
 ?
Ii protein + H2O inhibition of Ii degradation in enzyme-deficient cells leads to accumulation of Ii degradation intermediates in endosomal/lysosomal compartments Mus musculus C57BL/6 Ii fragments
-
 ?
Ii protein + H2O Ii invariant chain Mus musculus C57BL/6 Ii fragments
-
 ?
additional information cathepsin S in professional antigen-presenting cells, APC, controls MHC class II-mediated antigen presentation by epithelial cells in vivo, and plays a critical role in invariant chain degradation Mus musculus ?
-
 ?
additional information cathepsin S in professional antigen-presenting cells, APC, controls MHC class II-mediated antigen presentation by epithelial cells in vivo, and plays a critical role in invariant chain degradation Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
Cat S
-
 Mus musculus