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Literature summary for 3.4.22.27 extracted from

  • Liu, J.; Ma, L.; Yang, J.; Ren, A.; Sun, Z.; Yan, G.; Sun, J.; Fu, H.; Xu, W.; Hu, C.; Shi, G.P.
    Increased serum cathepsin S in patients with atherosclerosis and diabetes (2006), Atherosclerosis, 186, 411-419.
    View publication on PubMed
Search for more literature for 3.4.22.27

Application

Application Comment Organism
diagnostics an increased serum level of cathepsin S may serve as a biomarker for atherosclerosis and diabetes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cystatin C endogenous specific inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular serum Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens elastolytic enzyme activity of cathepsin S in artherosclerotic lesions, degradation of aortic elastin contributing to atherosclerosis and diabetes ?
-
 ?
additional information Homo sapiens serum cathepsin S is increased in patients with atherosclerosis and diabetes, the cystatin C level might play a role in disease development, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum increased serum cathepsin S in patients with atherosclerosis and diabetes Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 Cat S activity quantification in serum of healthy persons and atherosclerosis and/or diabetes patients, non-atheroma, and atheroma patients with myocardial infarction, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O elastolytic enzyme activity of cathepsin S in artherosclerotic lesions, degradation of aortic elastin contributing to atherosclerosis and diabetes Homo sapiens ?
-
 ?
Elastin + H2O degradation, elastolytic enzyme activity of cathepsin S Homo sapiens ?
-
 ?
additional information serum cathepsin S is increased in patients with atherosclerosis and diabetes, the cystatin C level might play a role in disease development, overview Homo sapiens ?
-
 ?