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Literature summary for 3.4.22.27 extracted from

  • Thurmond, R.L.; Sun, S.; Sehon, C.A.; Baker, S.M.; Cai, H.; Gu, Y.; Jiang, W.; Riley, J.P.; Williams, K.N.; Edwards, J.P.; Karlsson, L.
    Identification of a potent and selective noncovalent cathepsin S inhibitor (2004), J. Pharmacol. Exp. Ther., 308, 268-276.
    View publication on PubMed
Search for more literature for 3.4.22.27

Application

Application Comment Organism
medicine
-
 Mus musculus
medicine the inhibitor JNJ 10329670 is a candidate for immunosuppressive therapy of allergies and autoimmune diseases, completely reversible inhibition Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed by using the baculovirus expression system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
JNJ 10329670
-
 Bos taurus
JNJ 10329670
-
 Canis lupus familiaris
JNJ 10329670 CAS: 400797-24-2, the inhibitor blocks the presentation of tetanus toxoid and giant ragweed by human PBMCs, the inhibitor is a candidate for immunosuppressive therapy of allergies and autoimmune diseases, completely reversible inhibition Homo sapiens
JNJ 10329670
-
 Mus musculus
JNJ 10329670
-
 Platyrrhini

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus
-
 ?
-
 ?
additional information Canis lupus familiaris
-
 ?
-
 ?
additional information Homo sapiens cathepsin S is considered crucial for normal presentation of major histocompatibility complex class II-restricted antigens by antigen presenting cells to CD4+ T cells. It is a key enzyme for the degradation of the class II-associated invariant chain, a process that is required for effective antigen loading of class II molecules ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Canis lupus familiaris
-
 beagle
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Platyrrhini
-
 mature female cynomolgus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
 Mus musculus ?
-
 ?
additional information
-
 Canis lupus familiaris ?
-
 ?
additional information cathepsin S is considered crucial for normal presentation of major histocompatibility complex class II-restricted antigens by antigen presenting cells to CD4+ T cells. It is a key enzyme for the degradation of the class II-associated invariant chain, a process that is required for effective antigen loading of class II molecules Homo sapiens ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000034
-
 JNJ 10329670 pH 5.0 Homo sapiens
0.000124
-
 JNJ 10329670 pH 5.0 Canis lupus familiaris
0.000266
-
 JNJ 10329670 pH 5.0 Platyrrhini
0.000411
-
 JNJ 10329670 pH 5.0 Bos taurus
0.002364
-
 JNJ 10329670 pH 5.0 Mus musculus