Crystallization (Comment) | Organism |
---|---|
cathepsin S mixed with morpholine-4-carboxylic acid [1S-(2-benzyloxy-1R-cyano-ethylcarbamoyl)-3-methylbutyl]amide, crystals are grown by vapor diffusion at room temperature in hanging drops | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
morpholine-4-carboxylic acid [1R-(1S-cyano-3-phenyl-propylcarbamoyl)-1,3-dimethyl-butyl]-amide | - |
Homo sapiens | |
morpholine-4-carboxylic acid [1R-(1S-cyano-3-phenyl-propylcarbamoyl)-3-methylbutyl]amide | IC50: 0.011 mM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1R-cyano-3-phenylpropylcarbamoyl)-3-methylbutyl]amide | IC50: 387 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyano-2,2-dimethylpropylcarbamoyl)-3-methylbutyl]amide | IC50: 0.107 mM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyano-2-methyl-propylcarbamoyl)-3-methylbutyl]amide | IC50: 1400 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyano-2-phenylethylcarbamoyl)-3-methylbutyl]amide | IC50: 130 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenyl-propylcarbamoyl)-1,3-dimethyl-butyl]-amide | IC50: 0.076 mM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-2-cyclohexyl-ethyl]-amide | IC50: 5 mM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-2-methyl-propyl]-amide | IC50: 0.006 mM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-2-phenyl-ethyl]-amide | IC50: 173 mM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-3,3-dimethyl-butyl]-amide | IC50: 23 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-cyclohexyl-R-methyl]-amide | IC50: 84 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-ethyl]-amide | IC50: 0.134 mM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-pentyl]-amide | IC50: 41 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyanobutylcarbamoyl)-3-methylbutyl]amide | IC50: 82 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyanobutylcarbamoyl)-3-methylpentyl]amide | IC50: 56 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(1S-cyanomethylcarbamoyl)-3-methylbutyl]amide | IC50: 142 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(2-benzyloxy-1R-cyano-ethylcarbamoyl)-3-methylbutyl]amide | IC50: 19 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-(cyanomethylcarbamoyl)-3-methylbutyl]amide | IC50: 124 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-[(1-cyano-1-methyl)ethylcarbamoyl]-3-methylbutyl]amide | IC50: 114 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-[(cyano-phenyl-S-methyl)carbamoyl]-3-methylbutyl]amide | IC50: 51 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-[1S-cyano-2-(3,4-dichlorophenyl)ethylcarbamoyl]-3-methylbutyl]amide | IC50: 56 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-[2-(2-chlorobenzyloxy)-1R-cyanoethylcarbamoyl]-3-methylbutyl]amide | 9 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-[2-(3-chlorobenzyloxy)-1R-cyanoethylcarbamoyl]-3-methylbutyl]amide | 9 nM | Homo sapiens | |
morpholine-4-carboxylic acid [1S-[2-(4-chlorobenzyloxy)-1R-cyanoethylcarbamoyl]-3-methylbutyl]amide | 27 nM | Homo sapiens | |
morpholine-4-carboxylic acid [3-methyl-1S-(1-prop-2-ynylcarbamoyl)butyl]amide | IC50: 0.097 m | Homo sapiens | |
morpholine-4-carboxylic acid [3-methyl-1S-(1R-methyl-3-phenylpropylcarbamoyl)butyl]amide | IC50 above 0.339 mM | Homo sapiens | |
morpholine-4-carboxylic acid [3-methyl-1S-(3-phenyl-propylcarbamoyl)butyl]amide | IC50 above 0.028 mM | Homo sapiens | |
[1S-(1S-cyano-3-phenylpropylcarbamoyl)-3-methylbutyl]-amide | IC50: 42 nM | Homo sapiens | |
[1S-(2-cyano-1S-phenethyl-ethylcarbamoyl)-3-methylbutyl]amide | IC50 above 0.02 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000019 | - |
IC50: 19 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-(2-benzyloxy-1R-cyano-ethylcarbamoyl)-3-methylbutyl]amide | |
0.000023 | - |
IC50: 23 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-3,3-dimethyl-butyl]-amide | |
0.000041 | - |
IC50: 41 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-pentyl]-amide | |
0.000042 | - |
IC50: 42 nM | Homo sapiens | [1S-(1S-cyano-3-phenylpropylcarbamoyl)-3-methylbutyl]-amide | |
0.000051 | - |
IC50: 51 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-[(cyano-phenyl-S-methyl)carbamoyl]-3-methylbutyl]amide | |
0.000056 | - |
IC50: 56 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyanobutylcarbamoyl)-3-methylpentyl]amide | |
0.000056 | - |
IC50: 56 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-[1S-cyano-2-(3,4-dichlorophenyl)ethylcarbamoyl]-3-methylbutyl]amide | |
0.000082 | - |
IC50: 82 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyanobutylcarbamoyl)-3-methylbutyl]amide | |
0.000084 | - |
IC50: 84 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-cyclohexyl-R-methyl]-amide | |
0.000114 | - |
IC50: 114 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-[(1-cyano-1-methyl)ethylcarbamoyl]-3-methylbutyl]amide | |
0.000124 | - |
IC50: 124 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-(cyanomethylcarbamoyl)-3-methylbutyl]amide | |
0.00013 | - |
IC50: 130 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyano-2-phenylethylcarbamoyl)-3-methylbutyl]amide | |
0.000142 | - |
IC50: 142 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyanomethylcarbamoyl)-3-methylbutyl]amide | |
0.000387 | - |
IC50: 387 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1R-cyano-3-phenylpropylcarbamoyl)-3-methylbutyl]amide | |
0.0014 | - |
IC50: 1400 nM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyano-2-methyl-propylcarbamoyl)-3-methylbutyl]amide | |
0.006 | - |
IC50: 0.006 mM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-2-methyl-propyl]-amide | |
0.011 | - |
IC50: 0.011 mM | Homo sapiens | morpholine-4-carboxylic acid [1R-(1S-cyano-3-phenyl-propylcarbamoyl)-3-methylbutyl]amide | |
0.02 | - |
IC50 above 0.02 mM | Homo sapiens | [1S-(2-cyano-1S-phenethyl-ethylcarbamoyl)-3-methylbutyl]amide | |
0.028 | - |
IC50 above 0.028 mM | Homo sapiens | morpholine-4-carboxylic acid [3-methyl-1S-(3-phenyl-propylcarbamoyl)butyl]amide | |
0.076 | - |
IC50: 0.076 mM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenyl-propylcarbamoyl)-1,3-dimethyl-butyl]-amide | |
0.097 | - |
IC50: 0.097 mM | Homo sapiens | morpholine-4-carboxylic acid [3-methyl-1S-(1-prop-2-ynylcarbamoyl)butyl]amide | |
0.107 | - |
IC50: 0.107 mM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyano-2,2-dimethylpropylcarbamoyl)-3-methylbutyl]amide | |
0.134 | - |
IC50: 0.134 mM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-ethyl]-amide | |
0.339 | - |
IC50 above 0.339 mM | Homo sapiens | morpholine-4-carboxylic acid [3-methyl-1S-(1R-methyl-3-phenylpropylcarbamoyl)butyl]amide | |
5 | - |
IC50: 5 mM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-2-cyclohexyl-ethyl]-amide | |
173 | - |
IC50: 173 mM | Homo sapiens | morpholine-4-carboxylic acid [1S-(1S-cyano-3-phenylpropylcarbamoyl)-2-phenyl-ethyl]-amide |