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Literature summary for 3.4.22.27 extracted from

  • Mason, R.W.; Sol-Church, K.; Abrahamson, M.
    Amino acid substitutions in the N-terminal segment of cystatin C create selective protein inhibitors of lysosomal cysteine proteinases (1998), Biochem. J., 330, 833-838.
No PubMed abstract available
Search for more literature for 3.4.22.27

Inhibitors

Inhibitors Comment Organism Structure
cystatin C wild-type and mutant forms Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
 Bos taurus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information Ki-value for wild-type cystatin C, and the mutant cystatins V10F, V10W, V10R, and L9W are below 0.01 nM Bos taurus
0.00000001
-
 cystatin C mutant L9W/W106G pH 7.0, 37°C Bos taurus
0.000000011
-
 cystatin C mutant V10F/W106G pH 7.0, 37°C Bos taurus
0.00000011
-
 cystatin C mutant W106G pH 7.0, 37°C Bos taurus
0.00000019
-
 cystatin C mutant V10W/W106G pH 7.0, 37°C Bos taurus
0.0000015
-
 cystatin C mutant V10R/W106G pH 7.0, 37°C Bos taurus