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Literature summary for 3.4.22.27 extracted from
- Evaluation of dipeptide alpha-keto-beta-aldehydes as new inhibitors of cathepsin S (2000), Biochem. Biophys. Res. Commun., 275, 401-405.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzyloxycarbonyl-Ala-Leu-COCHO | - |
Homo sapiens |  |
| benzyloxycarbonyl-Phe-Ala-COCHO | - |
Homo sapiens | |
| Benzyloxycarbonyl-Phe-Arg | - |
Homo sapiens | |
| benzyloxycarbonyl-Phe-Arg-COCHO | - |
Homo sapiens | |
| benzyloxycarbonyl-Phe-Leu-COCHO | potent, reversible cathepsin S inhibitor, the inhibitor is 400fold more selective for cathepsin S than for cathepsin B | Homo sapiens | |
| benzyloxycarbonyl-Phe-Tyr(OBut)-COCHO | - |
Homo sapiens | |
| CLIK-060 | 0.001 mM, complete inhibition | Homo sapiens | |
| CLIK-066 | 0.01 mM, 28% inhibition | Homo sapiens | |
| CLIK-088 | 0.01 mM, 64% inhibition | Homo sapiens | |
| CLIK-112 | 0.01 mM, 77% inhibition | Homo sapiens | |
| CLIK-121 | 0.01 mM, complete inhibition | Homo sapiens | |
| CLIK-148 | 0.01 mM, complete inhibition | Homo sapiens | |
| CLIK-181 | 0.01 mM, 80% inhibition | Homo sapiens | |
| CLIK-195 | 0.01 mM, complete inhibition | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000000185 | - |
benzyloxycarbonyl-Phe-Leu-COCHO | pH 6.4, 25°C | Homo sapiens | |
| 0.00000223 | - |
benzyloxycarbonyl-Phe-Tyr(OBut)-COCHO | pH 6.4, 25°C | Homo sapiens | |
| 0.0000024 | - |
Benzyloxycarbonyl-Phe-Arg | pH 6.4, 25°C | Homo sapiens | |
| 0.0000232 | - |
benzyloxycarbonyl-Phe-Ala-COCHO | pH 6.4, 25°C | Homo sapiens | |
| 0.0027 | - |
benzyloxycarbonyl-Ala-Leu-COCHO | pH 6.4, 25°C | Homo sapiens | |
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