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Literature summary for 3.4.22.26 extracted from

  • Hoffman, E.A.; Gizelska, K.; Mirowski, M.; Mielicki, W.
    Arsenic trioxide downregulates cancer procoagulant activity in MCF-7 and WM-115 cell lines in vitro (2015), Contemp. Oncol. (Pozn.), 19, 108-112 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
inactive factor X + H2O Homo sapiens activation of blood coagulation factor X active factor Xa + ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell breast cancer cell line Homo sapiens
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WM-115 cell malignant melanoma cell line Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inactive factor X + H2O activation of blood coagulation factor X Homo sapiens active factor Xa + ?
-
 ?

Expression

Organism Comment Expression
Homo sapiens arsenic trioxide downregulates cancer procoagulant activity in MCF-7 and WM-115 cell lines in vitro and inhibits the proliferation of MCF-7 and WM-115 cells in vivo. all-trans Retinoic acid (ATRA) downregulates the expression of cancer procoagulant in breast cancer cells. Cancer procoagulant activity assay, overview down

General Information

General Information Comment Organism
evolution cancer procoagulant belongs to cysteine proteinase superfamily Homo sapiens
physiological function cancer procoagulant directly activates blood coagulation factor X in absence of activated factor VII. Cancer procoagulant is described in malignant and fetal, but not in normally differentiated tissues. Cancer procoagulant has proadhesive properties together with factor X-activating activity Homo sapiens