BRENDA - Enzyme Database show
show all sequences of 3.4.22.26

Biochemistry of cancer procoagulant

Mielicki, W.P.; Haemostasis 31 Suppl 1, 8-10 (2001)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Ca2+
required, 7 mM
Homo sapiens
Ca2+
-
Oryctolagus cuniculus
Cd2+
required, 1 mM
Homo sapiens
Cd2+
-
Oryctolagus cuniculus
Mg2+
required, 7 mM
Homo sapiens
Mg2+
-
Oryctolagus cuniculus
Mn2+
required, 0.1 mM
Homo sapiens
Mn2+
-
Oryctolagus cuniculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
antipain
-
Homo sapiens
antipain
-
Oryctolagus cuniculus
Cu2+
inactivation
Homo sapiens
Cu2+
inactivation
Oryctolagus cuniculus
Fe2+
inactivation
Homo sapiens
Fe2+
inactivation
Oryctolagus cuniculus
iodoacetamide
-
Oryctolagus cuniculus
iodoacetamide
-
Homo sapiens
leupeptin
-
Homo sapiens
leupeptin
-
Oryctolagus cuniculus
Mercuric chloride
-
Homo sapiens
Mercuric chloride
-
Oryctolagus cuniculus
additional information
no inhibition by alpha2-macroglobulin, alpha1-antiprotease, antithrombin III/heparin, cystatin, cysteamine, alpha1-anichymotrypsin, the effectiveness of most of the inhibitors increase in presence of reducing agents
Homo sapiens
p-chloromercuric benzoate
-
Homo sapiens
Peptidyl diazomethyl ketones
-
Homo sapiens
Peptidyl diazomethyl ketones
-
Oryctolagus cuniculus
PMSF
-
Homo sapiens
PMSF
-
Oryctolagus cuniculus
Sn2+
inactivation
Homo sapiens
Sn2+
inactivation
Oryctolagus cuniculus
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
i.e. E-64, reversible, competitive
Homo sapiens
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
ie.e. E-64, reversible, competitive
Oryctolagus cuniculus
Zn2+
inactivation
Homo sapiens
Zn2+
inactivation
Oryctolagus cuniculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Homo sapiens
16020
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
additional information
divalent metal ions are responsible for correct conformation of the enzyme, enzyme contains 2 metal binding sites: 1 for Ca2+ and Mg2+ binding, and 1 for Mn2+ and Cd2+ binding
Homo sapiens
additional information
divalent metal ions are responsible for correct conformation of the enzyme, enzyme contains 2 metal binding sites: 1 for Ca2+ and Mg2+ binding, and 1 for Mn2+ and Cd2+ binding
Oryctolagus cuniculus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
68000
-
-
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
factor X + H2O
Homo sapiens
cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade
factor Xa
-
Homo sapiens
?
factor X + H2O
Oryctolagus cuniculus
cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade
factor Xa
-
Oryctolagus cuniculus
?
additional information
Homo sapiens
enzyme seems to be regulated allosterically
?
-
Homo sapiens
?
PAR-1 receptor + H2O
Homo sapiens
-
?
-
Homo sapiens
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
no glycoprotein
-
Homo sapiens
no glycoprotein
-
Oryctolagus cuniculus
Purification (Commentary)
Commentary
Organism
-
Oryctolagus cuniculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
amnion
-
Homo sapiens
-
carcinoma cell
V2 carcinoma cell
Oryctolagus cuniculus
-
chorion
-
Homo sapiens
-
leukemia cell
-
Homo sapiens
-
additional information
produced by malignant and fetal cells
Oryctolagus cuniculus
-
additional information
produced by malignant and fetal cells
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-Ala-Pro-Arg-4-nitroanilide + H2O
-
651435
Homo sapiens
D-Ala-Pro-Arg + 4-nitroaniline
-
651435
Homo sapiens
?
D-Ile-Pro-Arg-4-nitroanilide + H2O
-
651435
Homo sapiens
D-Ile-Pro-Arg + 4-nitroaniline
-
651435
Homo sapiens
?
factor X + H2O
cleavage of Arg-Ile bond
651435
Oryctolagus cuniculus
factor Xa
-
651435
Oryctolagus cuniculus
?
factor X + H2O
cleavage of Arg-Ile bond in factor X heavy chain
651435
Homo sapiens
factor Xa
-
651435
Homo sapiens
?
factor X + H2O
cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade
651435
Homo sapiens
factor Xa
-
651435
Homo sapiens
?
factor X + H2O
cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade
651435
Oryctolagus cuniculus
factor Xa
-
651435
Oryctolagus cuniculus
?
Glu-Glu-Pro-Arg-4-nitroanilide + H2O
-
651435
Homo sapiens
Glu-Glu-Pro-Arg + 4-nitroaniline
-
651435
Homo sapiens
?
additional information
substrate recognition depends on the secondary and tertiary configuration of the protein substrate rather than on the primary sequence alone, no activity with substrates containing the sequence Xaa-Lys-ProP2-TyrP1-
651435
Homo sapiens
?
-
651435
Homo sapiens
?
additional information
enzyme seems to be regulated allosterically
651435
Homo sapiens
?
-
651435
Homo sapiens
?
N-p-tosyl-Gly-Pro-Arg-4-nitroanilide + H2O
-
651435
Homo sapiens
N-p-tosyl-Gly-Pro-Arg + 4-nitroaniline
-
651435
Homo sapiens
?
N-p-tosyl-Gly-Pro-Lys-4-nitroanilide + H2O
-
651435
Homo sapiens
N-p-tosyl-Gly-Pro-Lys + 4-nitroaniline
-
651435
Homo sapiens
?
PAR-1 receptor + H2O
-
651435
Homo sapiens
?
-
651435
Homo sapiens
?
PAR-1 receptor + H2O
enzyme competes with thrombin for the same protease-activated receptor, i.e. PAR-1, on the blood platelet surface
651435
Homo sapiens
?
-
651435
Homo sapiens
?
Subunits
Subunits
Commentary
Organism
monomer
1 * 68000
Oryctolagus cuniculus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.128
-
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
Homo sapiens
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Oryctolagus cuniculus
-
-
4.8
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Ca2+
required, 7 mM
Homo sapiens
Ca2+
-
Oryctolagus cuniculus
Cd2+
required, 1 mM
Homo sapiens
Cd2+
-
Oryctolagus cuniculus
Mg2+
required, 7 mM
Homo sapiens
Mg2+
-
Oryctolagus cuniculus
Mn2+
required, 0.1 mM
Homo sapiens
Mn2+
-
Oryctolagus cuniculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
antipain
-
Homo sapiens
antipain
-
Oryctolagus cuniculus
Cu2+
inactivation
Homo sapiens
Cu2+
inactivation
Oryctolagus cuniculus
Fe2+
inactivation
Homo sapiens
Fe2+
inactivation
Oryctolagus cuniculus
iodoacetamide
-
Oryctolagus cuniculus
iodoacetamide
-
Homo sapiens
leupeptin
-
Homo sapiens
leupeptin
-
Oryctolagus cuniculus
Mercuric chloride
-
Homo sapiens
Mercuric chloride
-
Oryctolagus cuniculus
additional information
no inhibition by alpha2-macroglobulin, alpha1-antiprotease, antithrombin III/heparin, cystatin, cysteamine, alpha1-anichymotrypsin, the effectiveness of most of the inhibitors increase in presence of reducing agents
Homo sapiens
p-chloromercuric benzoate
-
Homo sapiens
Peptidyl diazomethyl ketones
-
Homo sapiens
Peptidyl diazomethyl ketones
-
Oryctolagus cuniculus
PMSF
-
Homo sapiens
PMSF
-
Oryctolagus cuniculus
Sn2+
inactivation
Homo sapiens
Sn2+
inactivation
Oryctolagus cuniculus
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
i.e. E-64, reversible, competitive
Homo sapiens
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
ie.e. E-64, reversible, competitive
Oryctolagus cuniculus
Zn2+
inactivation
Homo sapiens
Zn2+
inactivation
Oryctolagus cuniculus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.128
-
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Homo sapiens
16020
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
additional information
divalent metal ions are responsible for correct conformation of the enzyme, enzyme contains 2 metal binding sites: 1 for Ca2+ and Mg2+ binding, and 1 for Mn2+ and Cd2+ binding
Homo sapiens
additional information
divalent metal ions are responsible for correct conformation of the enzyme, enzyme contains 2 metal binding sites: 1 for Ca2+ and Mg2+ binding, and 1 for Mn2+ and Cd2+ binding
Oryctolagus cuniculus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
68000
-
-
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
factor X + H2O
Homo sapiens
cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade
factor Xa
-
Homo sapiens
?
factor X + H2O
Oryctolagus cuniculus
cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade
factor Xa
-
Oryctolagus cuniculus
?
additional information
Homo sapiens
enzyme seems to be regulated allosterically
?
-
Homo sapiens
?
PAR-1 receptor + H2O
Homo sapiens
-
?
-
Homo sapiens
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
no glycoprotein
-
Homo sapiens
no glycoprotein
-
Oryctolagus cuniculus
Purification (Commentary) (protein specific)
Commentary
Organism
-
Oryctolagus cuniculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
amnion
-
Homo sapiens
-
carcinoma cell
V2 carcinoma cell
Oryctolagus cuniculus
-
chorion
-
Homo sapiens
-
leukemia cell
-
Homo sapiens
-
additional information
produced by malignant and fetal cells
Oryctolagus cuniculus
-
additional information
produced by malignant and fetal cells
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-Ala-Pro-Arg-4-nitroanilide + H2O
-
651435
Homo sapiens
D-Ala-Pro-Arg + 4-nitroaniline
-
651435
Homo sapiens
?
D-Ile-Pro-Arg-4-nitroanilide + H2O
-
651435
Homo sapiens
D-Ile-Pro-Arg + 4-nitroaniline
-
651435
Homo sapiens
?
factor X + H2O
cleavage of Arg-Ile bond
651435
Oryctolagus cuniculus
factor Xa
-
651435
Oryctolagus cuniculus
?
factor X + H2O
cleavage of Arg-Ile bond in factor X heavy chain
651435
Homo sapiens
factor Xa
-
651435
Homo sapiens
?
factor X + H2O
cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade
651435
Homo sapiens
factor Xa
-
651435
Homo sapiens
?
factor X + H2O
cleavage of Arg-Ile bond in factor X heavy chain, activation of the coaglutation factor X and thereby activation of the plasma blood clotting cascade
651435
Oryctolagus cuniculus
factor Xa
-
651435
Oryctolagus cuniculus
?
Glu-Glu-Pro-Arg-4-nitroanilide + H2O
-
651435
Homo sapiens
Glu-Glu-Pro-Arg + 4-nitroaniline
-
651435
Homo sapiens
?
additional information
substrate recognition depends on the secondary and tertiary configuration of the protein substrate rather than on the primary sequence alone, no activity with substrates containing the sequence Xaa-Lys-ProP2-TyrP1-
651435
Homo sapiens
?
-
651435
Homo sapiens
?
additional information
enzyme seems to be regulated allosterically
651435
Homo sapiens
?
-
651435
Homo sapiens
?
N-p-tosyl-Gly-Pro-Arg-4-nitroanilide + H2O
-
651435
Homo sapiens
N-p-tosyl-Gly-Pro-Arg + 4-nitroaniline
-
651435
Homo sapiens
?
N-p-tosyl-Gly-Pro-Lys-4-nitroanilide + H2O
-
651435
Homo sapiens
N-p-tosyl-Gly-Pro-Lys + 4-nitroaniline
-
651435
Homo sapiens
?
PAR-1 receptor + H2O
-
651435
Homo sapiens
?
-
651435
Homo sapiens
?
PAR-1 receptor + H2O
enzyme competes with thrombin for the same protease-activated receptor, i.e. PAR-1, on the blood platelet surface
651435
Homo sapiens
?
-
651435
Homo sapiens
?
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 68000
Oryctolagus cuniculus
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Oryctolagus cuniculus
-
-
4.8
Other publictions for EC 3.4.22.26
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733446
Kee
The effect of cancer procoagul ...
Homo sapiens
Biol. Chem.
393
113-121
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
701292
Musallam
Incidence and prophylaxis of v ...
Homo sapiens
Thromb. Res.
123
679-686
2009
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710603
Kaplinska
Cancer procoagulant (CP) analy ...
Homo sapiens
Thromb. Res.
124
364-367
2009
-
-
-
-
-
-
2
-
1
2
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
2
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697471
Kamocka
Rat prostate tumors express ca ...
Rattus norvegicus
Comp. Med.
58
282-286
2008
-
-
-
-
-
-
2
-
-
-
-
2
-
3
-
-
1
-
-
2
11
-
3
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
1
2
-
-
-
-
-
2
-
-
-
1
-
2
11
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
679297
Kamocka
Effect of immunisation with ca ...
Homo sapiens
Clin. Exp. Med.
6
119-123
2006
-
1
-
-
-
-
1
-
-
1
-
-
-
4
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679638
Szajda
Analysis of the relationship b ...
Homo sapiens
Eur. J. Gynaecol. Oncol.
27
495-499
2006
1
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668075
Kazmierczak
Cancer procoagulant in patient ...
Homo sapiens
Blood Coagul. Fibrinolysis
16
543-547
2005
-
-
-
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
4
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
4
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668137
Kamocka
Effect of cancer procoagulant ...
Homo sapiens
Cancer Lett.
222
89-94
2005
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
1
-
-
3
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
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