BRENDA - Enzyme Database show
show all sequences of 3.4.22.26

Effect of divalent ions on the activity of cancer procoagulant

Mielicki, W.P.; Kozwich, D.L.; Kramer, L.C.; Gordon, S.G.; Arch. Biochem. Biophys. 314, 165-170 (1994)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
Fe2+
in the presence of Ca2+, complete inactivation at 1 mM Fe2+ and above
Homo sapiens
Mn2+
above 1 mM, activates below 1 mM
Homo sapiens
Zn2+
in the presence of Ca2+, complete inactivation at 1 mM Zn2+ and above
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Homo sapiens
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
below 1 mM Mn2+, additive effect in the presence of Mn2+; immunoimmobilized enzyme does not require Ca2+
Homo sapiens
Mg2+
5 mM; no additive effect of Ca2+ and Mg2+, immunoimmobilized enzyme does not require Mg2+; requirement, can replace Ca2+
Homo sapiens
Mn2+
below 1 mM, additive effect in the presence of Ca2+; immunoimmobilized enzyme does not require Mn2+; inhibits above 1 mM; requirement, can replace Ca2+
Homo sapiens
additional information
binding cancer procoagulant to a surface changes its divalent ion requirements; no activation by Fe2+ or Zn2+ in the absence of Ca2+
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
placenta
amnion-chorion tissue
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
specific activity in various rat tissues
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Factor X + H2O
-
30161
Homo sapiens
Factor Xa + ?
-
30161
Homo sapiens
-
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Fe2+
in the presence of Ca2+, complete inactivation at 1 mM Fe2+ and above
Homo sapiens
Mn2+
above 1 mM, activates below 1 mM
Homo sapiens
Zn2+
in the presence of Ca2+, complete inactivation at 1 mM Zn2+ and above
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Homo sapiens
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
below 1 mM Mn2+, additive effect in the presence of Mn2+; immunoimmobilized enzyme does not require Ca2+
Homo sapiens
Mg2+
5 mM; no additive effect of Ca2+ and Mg2+, immunoimmobilized enzyme does not require Mg2+; requirement, can replace Ca2+
Homo sapiens
Mn2+
below 1 mM, additive effect in the presence of Ca2+; immunoimmobilized enzyme does not require Mn2+; inhibits above 1 mM; requirement, can replace Ca2+
Homo sapiens
additional information
binding cancer procoagulant to a surface changes its divalent ion requirements; no activation by Fe2+ or Zn2+ in the absence of Ca2+
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
placenta
amnion-chorion tissue
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
specific activity in various rat tissues
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Factor X + H2O
-
30161
Homo sapiens
Factor Xa + ?
-
30161
Homo sapiens
-
Other publictions for EC 3.4.22.26
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733446
Kee
The effect of cancer procoagul ...
Homo sapiens
Biol. Chem.
393
113-121
2012
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3
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-
1
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1
-
-
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-
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-
-
-
-
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1
1
-
-
-
701292
Musallam
Incidence and prophylaxis of v ...
Homo sapiens
Thromb. Res.
123
679-686
2009
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-
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1
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2
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1
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710603
Kaplinska
Cancer procoagulant (CP) analy ...
Homo sapiens
Thromb. Res.
124
364-367
2009
-
-
-
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2
-
1
2
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2
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2
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1
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2
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1
2
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2
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1
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697471
Kamocka
Rat prostate tumors express ca ...
Rattus norvegicus
Comp. Med.
58
282-286
2008
-
-
-
-
-
-
2
-
-
-
-
2
-
3
-
-
1
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-
2
11
-
3
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1
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1
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1
2
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2
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1
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2
11
-
3
-
-
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-
-
1
-
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-
-
-
-
-
-
679297
Kamocka
Effect of immunisation with ca ...
Homo sapiens
Clin. Exp. Med.
6
119-123
2006
-
1
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1
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1
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4
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1
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2
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1
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1
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1
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1
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1
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2
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1
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679638
Szajda
Analysis of the relationship b ...
Homo sapiens
Eur. J. Gynaecol. Oncol.
27
495-499
2006
1
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1
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2
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3
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1
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1
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1
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3
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1
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-
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-
668075
Kazmierczak
Cancer procoagulant in patient ...
Homo sapiens
Blood Coagul. Fibrinolysis
16
543-547
2005
-
-
-
-
-
-
-
-
1
-
-
2
-
2
-
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4
1
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2
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1
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2
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4
1
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2
-
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-
-
-
-
-
-
-
-
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-
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-
668137
Kamocka
Effect of cancer procoagulant ...
Homo sapiens
Cancer Lett.
222
89-94
2005
-
-
-
-
-
-
1
-
-
-
-
2
-
1
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1
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3
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3
-
1
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1
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1
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2
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1
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3
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3
-
1
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1
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-
668476
Jozwik
The activity of cancer procoag ...
Homo sapiens
Eur. J. Gynaecol. Oncol.
26
407-410
2005
-
-
-
-
-
-
-
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1
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2
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2
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7
1
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4
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1
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2
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7
1
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4
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-
667302
Raasi
Properties of proteins in canc ...
Homo sapiens
Arch. Biochem. Biophys.
428
131-135
2004
-
-
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2
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2
-
1
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1
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1
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1
1
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1
1
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2
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2
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1
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1
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1
1
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1
1
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651435
Mielicki
Biochemistry of cancer procoag ...
Homo sapiens, Oryctolagus cuniculus
Haemostasis
31 Suppl 1
8-10
2001
8
-
-
-
-
-
24
-
1
2
1
4
-
2
-
2
1
-
-
6
-
-
13
1
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-
-
-
-
-
-
-
1
1
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8
-
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-
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24
1
-
1
2
1
4
-
-
2
1
-
6
-
-
13
1
-
-
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-
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1
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-
653983
Mielicki
Cancer procoagulant activity s ...
Homo sapiens
Thromb. Res.
87
251-256
1997
-
1
-
-
-
-
2
5
-
-
-
1
-
1
-
-
1
-
-
3
2
-
18
-
-
-
-
5
1
-
-
-
-
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-
-
1
-
-
-
-
-
-
2
-
5
-
-
-
1
-
-
-
1
-
3
2
-
18
-
-
-
-
5
1
-
-
-
-
-
-
-
-
-
30160
Gordon
Cancer procoagulant ...
Homo sapiens, Rattus norvegicus
Methods Enzymol.
244
568-583
1994
2
-
-
-
-
6
26
-
-
8
2
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2
2
2
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-
7
-
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2
-
2
-
-
-
-
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-
2
-
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-
6
-
26
-
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-
8
2
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2
2
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-
7
-
-
2
-
2
-
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-
-
-
-
-
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-
30161
Mielicki
Effect of divalent ions on the ...
Homo sapiens
Arch. Biochem. Biophys.
314
165-170
1994
-
-
-
-
-
-
3
-
1
4
-
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1
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1
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1
1
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1
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3
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1
4
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1
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1
1
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1
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30159
Moore
The purification and propertie ...
Mus musculus
Biochem. Biophys. Res. Commun.
184
819-824
1992
-
-
-
-
-
-
12
-
1
1
1
1
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3
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1
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6
-
1
4
1
1
-
-
-
-
-
-
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-
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-
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12
-
-
1
1
1
1
-
-
-
1
-
6
-
1
4
1
1
-
-
-
-
-
-
-
-
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-
-
-
-
30158
Falanga
Inhibition of cancer procoagul ...
Oryctolagus cuniculus
Thromb. Res.
54
389-398
1989
-
-
-
-
-
-
2
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1
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3
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3
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30157
Falanga
Several murine metastasizing t ...
Mus musculus, Oryctolagus cuniculus
Int. J. Cancer
39
774-777
1987
-
-
-
-
-
-
-
-
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4
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4
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8
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6
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4
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8
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6
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30156
Falanga
Isolation and characterization ...
Oryctolagus cuniculus
Biochemistry
24
5558-5567
1985
-
-
-
-
-
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2
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2
1
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2
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1
1
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3
-
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2
1
1
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1
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2
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2
1
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1
1
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3
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2
1
1
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1
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