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Literature summary for 3.4.22.26 extracted from

  • Mielicki, W.P.; Kozwich, D.L.; Kramer, L.C.; Gordon, S.G.
    Effect of divalent ions on the activity of cancer procoagulant (1994), Arch. Biochem. Biophys., 314, 165-170.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Fe2+ in the presence of Ca2+, complete inactivation at 1 mM Fe2+ and above Homo sapiens
Mn2+ above 1 mM, activates below 1 mM Homo sapiens
Zn2+ in the presence of Ca2+, complete inactivation at 1 mM Zn2+ and above Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ below 1 mM Mn2+, additive effect in the presence of Mn2+ Homo sapiens
Ca2+ immunoimmobilized enzyme does not require Ca2+ Homo sapiens
Mg2+ 5 mM Homo sapiens
Mg2+ requirement, can replace Ca2+ Homo sapiens
Mg2+ no additive effect of Ca2+ and Mg2+, immunoimmobilized enzyme does not require Mg2+ Homo sapiens
Mn2+ requirement, can replace Ca2+ Homo sapiens
Mn2+ immunoimmobilized enzyme does not require Mn2+ Homo sapiens
Mn2+ below 1 mM, additive effect in the presence of Ca2+ Homo sapiens
Mn2+ inhibits above 1 mM Homo sapiens
additional information binding cancer procoagulant to a surface changes its divalent ion requirements Homo sapiens
additional information no activation by Fe2+ or Zn2+ in the absence of Ca2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta amnion-chorion tissue Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
specific activity in various rat tissues Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Factor X + H2O
-
Homo sapiens Factor Xa + ?
-
?