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Literature summary for 3.4.22.16 extracted from

  • D'Angelo, M.E.; Bird, P.I.; Peters, C.; Reinheckel, T.; Trapani, J.A.; Sutton, V.R.
    Cathepsin H is an additional convertase of pro-granzyme B (2010), J. Biol. Chem., 285, 20514-20519.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.16

Inhibitors

Inhibitors Comment Organism Structure
E-64 irreversible active site inhibitor Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Arg-7-amido-4-methylcoumarin + H2O
-
 Mus musculus L-Arg + 7-amino-4-methylcoumarin
-
 ?
pro-granzyme B + H2O cathepsin H has pro-granzyme B convertase activity in vitro Mus musculus granzyme B + ?
-
 ?

Synonyms

Synonyms Comment Organism
CatH
-
 Mus musculus

General Information

General Information Comment Organism
malfunction lymphocytes deficient in CatH are still capable of generating active granzyme B. CatH-deficient mice do not show a gross morphological phenotype and no impairment of reproductive capacity or breeding behavior or nursing Mus musculus