Literature summary for 3.4.22.16 extracted from

Horn, M.; Doleckova-Maresova, L.; Rulisek, L.; Masa, M.; Vasiljeva, O.; Turk, B.; Gan-Erdene, T.; Baudys, M.; Mares, M.
Activation processing of cathepsin H impairs recognition by its propeptide (2005), Biol. Chem., 386, 941-947.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	no significant inhibitory effect of enzyme propeptide fragments, detailed analysis using several different peptides. Recombinant enzyme lacking the mini-chain shows inhibitory interaction	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09668	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	propeptide-binding region of enzyme is structurally rearranged during maturation processing and mini-chain formation, which impairs the effective recognition of mature enzyme by its propeptide	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Arg-4-methylcoumaryl-7-amide + H2O	-	Homo sapiens	Arg + 7-amino-4-methylcoumarin	-	?
benzoyl-L-Phe-L-Val-L-Arg-4-methylcoumaryl-7-amide + H2O	-	Homo sapiens	benzoyl-L-Phe-L-Val-L-Arg + 7-amino-4-methylcoumarin	-	?

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Release 2023.1 (January 2023)