Literature summary for 3.4.22.16 extracted from

Hara, K.; Kominami, E.; Katunuma, N.
Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophages (1988), FEBS Lett., 231, 229-231.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	metalloendopeptidases involved in processing of procathepsin to active enzyme	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	inhibits processing of proenzyme to active form	Rattus norvegicus
benzyloxycarbonyl-Gly-Leu-NH	inhibits processing of proenzyme to active form	Rattus norvegicus
Benzyloxycarbonyl-Leu-NH2	inhibits formation of active enzyme from procathepsin H	Rattus norvegicus
ethyl(2S,3S)-3-(S)-3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl oxirane-2-carboxylate	E-64-d, inhibits processing of proenzyme to active form	Rattus norvegicus
leupeptin	inhibits processing of proenzyme to active form	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)