Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CLIK-148 | specific inhibitor of cathepsin L | Mus musculus | |
E-64 | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
secretory vesicle | - |
Mus musculus | 99503 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
BAM-22P + H2O | Mus musculus | - |
(Met)enkephalin + ? | - |
? | |
Cholecystokinin + H2O | Mus musculus | - |
? | - |
? | |
chromogranin A + H2O | Mus musculus | - |
catestatin | - |
? | |
pro-dynorphin + H2O | Mus musculus | - |
? | - |
? | |
pro-enkephalin + H2O | Mus musculus | - |
enkephalin + ? | - |
? | |
Pro-opiomelanocortin + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
BAM-22P + H2O | - |
Mus musculus | (Met)enkephalin + ? | - |
? | |
Cholecystokinin + H2O | - |
Mus musculus | ? | - |
? | |
chromogranin A + H2O | - |
Mus musculus | catestatin | - |
? | |
pro-dynorphin + H2O | - |
Mus musculus | ? | - |
? | |
pro-enkephalin + H2O | - |
Mus musculus | enkephalin + ? | - |
? | |
Pro-opiomelanocortin + H2O | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CatL | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | in cathepsin L knockou mice, brain levels of (Met)enkephalin are reduced to 44%, brain levels of neuropeptide Y are reduced to 22%, brain levels of cholecystokinin are reduced to 75%, brain levels of dynorphin A are reduced to 25% , brain levels of dynorphin B are reduced to 17%, brain levels of alpha-neoendorphin are reduced to 10%, brain levels of adrenocorticotropin hormone are reduced to 23%, brain levels of beta-endorphin are reduced to 18%, and brain levels of alpha-MSH are reduced to 7% of the wild type level | Mus musculus |
physiological function | cathepsin L in secretory vesicles functions as a key protease for proteolytic processing of proneuropeptides (including enkephalin, neuropeptide Y, dynorphins, cholecystokinin, and others) and prohormones into active neuropeptides that are released to mediate cell-cell communication in the nervous system for neurotransmission. Cathepsin L is a key protease responsible for cholecystokinin 8 production in brain | Mus musculus |