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Literature summary for 3.4.22.15 extracted from

  • Lankelma, J.M.; Voorend, D.M.; Barwari, T.; Koetsveld, J.; Van der Spek, A.H.; De Porto, A.P.; Van Rooijen, G.; Van Noorden, C.J.
    Cathepsin L, target in cancer treatment? (2010), Life Sci., 86, 225-233.
    View publication on PubMed
Search for more literature for 3.4.22.15

Application

Application Comment Organism
medicine cathepsin L inhibition in combination with conventional chemotherapy is a promising therapy in cancer treatment Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-naphthalenesulfonyl-Ile-Trp-aldehyde selective intra- and extracellular cathepsin L inhibitor Homo sapiens
benzyloxycarbonyl-L-Phe-L-Phe-fluoromethylketone irreversible and selective inhibitor of cathepsin L Homo sapiens
CLIK-148
-
 Homo sapiens
E-64 broad-spectrum cathepsin inhibitor, cathepsin L irreversible binding Homo sapiens
Ep-475 cathepsin L irreversible binding Homo sapiens
JPM-565 cathepsin L irreversible binding Homo sapiens
JPM-OEt cathepsin L irreversible binding Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome mature cathepsin L Homo sapiens 5764
-
secretory vesicle procathepsin L Homo sapiens 99503
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell
-
 Homo sapiens
-
glioma cell
-
 Homo sapiens
-
mandible
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
neuroblastoma cell
-
 Homo sapiens
-
oral squamous cell carcinoma cell
-
 Homo sapiens
-
osteosarcoma cell
-
 Homo sapiens
-
squamous cell carcinoma cell mandibular Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens expression of cathepsin L is not elevated in non-malignant tumor cells additional information
Homo sapiens expression of cathepsin L is elevated in cancer up

General Information

General Information Comment Organism
malfunction inhibition of cathepsin L can decrease metastatic tumor development Homo sapiens
physiological function cathepsin L plays a role in the immune system, in particular by degrading the invariant chain in MHC class II processing. Cathepsin L plays a part in recycling processes during axon outgrowth and synapse formation in the developing postnatal central nervous system Homo sapiens