Literature summary for 3.4.22.15 extracted from

Higgins, W.J.; Fox, D.M.; Kowalski, P.S.; Nielsen, J.E.; Worrall, D.M.
Heparin enhances serpin inhibition of the cysteine protease cathepsin L (2010), J. Biol. Chem., 285, 3722-3729.

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Inhibitors

Inhibitors	Comment	Organism	Structure
serpin B3	about 35% inhibition at 7.5 nM, the presence of heparin accelerates inhibition of cathepsin L by serpin B3 (4.1fold increase in rate of inhibition)	Homo sapiens
serpin B4	about 70% inhibition at 100 nM, the presence of 50 nM heparin accelerates inhibition of cathepsin L by serpin B4 (4.1fold increase in rate of inhibition)	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MDA-MB-231 cell	-	Homo sapiens	-
WM-793 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin	-	?

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Release 2023.1 (January 2023)