Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzyloxycarbonyl-L-Phe-L-Phe-fluoromethylketone | - |
Homo sapiens | |
benzyloxycarbonyl-L-Phe-L-Phe-fluoromethylketone | - |
Mus musculus | |
E-64d | - |
Homo sapiens | |
E-64d | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
perforin + H2O | Mus musculus | CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus | ? | - |
? | |
perforin + H2O | Homo sapiens | CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cytotoxic T-lymphocyte | - |
Mus musculus | - |
natural killer cell | - |
Homo sapiens | - |
NK-92 cell | - |
Homo sapiens | - |
YT cell | YT 5 cell | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin | - |
? | |
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin | - |
? | |
perforin + H2O | CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus | Mus musculus | ? | - |
? | |
perforin + H2O | CatL preferentially cleaves a site on full-length recombinant perforin close to its C terminus | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CatL | - |
Mus musculus |
CatL | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | granule-bound cathepsins are essential for processing perforin to its active form, and CatL is an important, but not exclusive, participant in this process | Mus musculus |
physiological function | granule-bound cathepsins are essential for processing perforin to its active form, and CatL is an important, but not exclusive, participant in this process | Homo sapiens |