Literature summary for 3.4.22.15 extracted from

Park, Y.; Kong, J.Y.; Cho, H.
A furanquinone from Paulownia tomentosa stem for a new cathepsin K inhibitor (2009), Phytother. Res., 23, 1485-1488.

Search for more literature for 3.4.22.15

Inhibitors

Inhibitors	Comment	Organism	Structure
methyl 5-acetyloxy-dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate	furanquinone from Paulownia tomentosa stem, inhibitory to both cathepsin L and cathepsin K	Homo sapiens
methyl 5-hydroxy-dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate	furanquinone from Paulownia tomentosa stem, inhibitory to both cathepsin L and cathepsin K	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0386	-	pH 5.5, 22°C	Homo sapiens	methyl 5-acetyloxy-dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate
0.0616	-	pH 5.5, 22°C	Homo sapiens	methyl 5-hydroxy-dinaphtho[1,2-2'3']furan-7,12-dione-6-carboxylate

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Release 2023.1 (January 2023)