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Literature summary for 3.4.22.15 extracted from

  • Navab, R.; Pedraza, C.; Fallavollita, L.; Wang, N.; Chevet, E.; Auguste, P.; Jenna, S.; You, Z.; Bikfalvi, A.; Hu, J.; OConnor, R.; Erickson, A.; Mort, J.S.; Brodt, P.
    Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels (2008), Oncogene, 27, 4973-4985.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information construction of cell lines with reduced expression of cathepsin L by stable transfection of H-59 cells with a plasmid expressing an antisense fragment of mouse cathepsin L cDNA. Transfected cells show a loss of IGF-I-induced receptor phosphorylation and Shc recruitment, reduced IGF-I (but not IGFII)-induced cellular proliferation and migration, decreased anchorage-independent growth and reduced plasma membrane levels of IGF type I receptor. Changes result in apoptosis in vivo and an impaired ability to form liver metastases Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus cathepsin L expression levels regulate cell responsiveness to IGF-type I, function for cathepsin L in the control of the tumorigenic/metastatic phenotype ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
H-59 cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin L expression levels regulate cell responsiveness to IGF-type I, function for cathepsin L in the control of the tumorigenic/metastatic phenotype Mus musculus ?
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 ?