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Literature summary for 3.4.22.15 extracted from

  • Haecker, H.G.; Grundmann, F.; Lohr, F.; Ottersbach, P.A.; Zhou, J.; Schnakenburg, G.; Guetschow, M.
    2-Amino- and 2-alkylthio-4H-3,1-benzothiazin-4-ones: synthesis, interconversion and enzyme inhibitory activities (2009), Molecules, 14, 378-402.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-[cyclohexyl(methyl)amino]-4H-3,1-benzothiazin-4-one selective towards cathepsin L over cathepsin G, chymotrypsin, trypsin, human angiotensin-converting enzyme, human leukocyte elastase, acetylcholinesterase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00893
-
37°C, pH 6.0 Homo sapiens 2-[cyclohexyl(methyl)amino]-4H-3,1-benzothiazin-4-one