Literature summary for 3.4.22.15 extracted from

Porotto, M.; Orefice, G.; Yokoyama, C.; Mungall, B.; Realubit, R.; Sganga, M.; Aljofan, M.; Whitt, M.; Glickman, F.; Moscona, A.
Simulating henipavirus multicycle replication in a screening assay leads to identification of a promising candidate for therapy (2009), J. Virol., 83, 5148-5155.

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Application

Application	Comment	Organism
pharmacology	chloroquine inhibits the infection with live Nipah virus and Hendra virus at a concentration of 1 microM in vitro. The mechanism for the antiviral action likely is the inhibition of cathepsin L, which is essential for the processing of the viral fusion glycoprotein and the maturation of newly budding virions	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Chloroquine	chloroquine inhibits the infection with live Nipah virus and Hendra virus at a concentration of 1 microM in vitro. The mechanism for the antiviral action likely is the inhibition of cathepsin L, which is essential for the processing of the viral fusion glycoprotein and the maturation of newly budding virions	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)