Literature summary for 3.4.22.15 extracted from

Yadav, M.R.; Shinde, A.K.; Chouhan, B.S.; Giridhar, R.; Menard, R.
Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors (2008), J. Enzyme Inhib. Med. Chem., 23, 190-197.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(E)N-[(S)1-[(S)2-cyano-1-pyrrolidinecarbonyl]-3-methylbutyl]-2,3-diphenylacrylamide	selective towards cathepsin L over cathepsin B	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0053	-	(E)N-[(S)1-[(S)2-cyano-1-pyrrolidinecarbonyl]-3-methylbutyl]-2,3-diphenylacrylamide	23°C, pH 6.0	Homo sapiens

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Release 2023.1 (January 2023)