Literature summary for 3.4.22.15 extracted from

Sullivan, S.; Tosetto, M.; Kevans, D.; Coss, A.; Wang, L.; ODonoghue, D.; Hyland, J.; Sheahan, K.; Mulcahy, H.; OSullivan, J.
Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer (2009), Int. J. Cancer, 125, 54-61.

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Application

Application	Comment	Organism
medicine	survival of patients with colorectal cancer is inversely associated with staining intensity in the epithelial cytoplasm and stromal nuclei. In different colorectal cell lines and in vivo tumors, pro- and active cathepsin L isoforms are present in both the cytoplasm and nuclear samples, with pro-cathepsin L at 50 kDa and active cathepsin L at 25 kDa. Purified nuclear and cytoplasmic fractions show cathepsin L activity	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
nucleus	-	Homo sapiens	5634	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
25000	-	x * 50000, pro-cathepsin L, x * 25000, mature form, SDS-PAGE	Homo sapiens
50000	-	x * 50000, pro-cathepsin L, x * 25000, mature form, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with colorectal cancer	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colonic cancer cell	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * 50000, pro-cathepsin L, x * 25000, mature form, SDS-PAGE	Homo sapiens

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Release 2023.1 (January 2023)