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Literature summary for 3.4.22.15 extracted from

  • Novinec, M.; Grass, R.N.; Stark, W.J.; Turk, V.; Baici, A.; Lenarcic, B.
    Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors (2007), J. Biol. Chem., 282, 7893-7902.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain BL21 (DE3) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
E-64 irreversible inhibitor Homo sapiens
kininogen domain 3
-
Homo sapiens
p41 fragment
-
Homo sapiens
Stefin A
-
Homo sapiens
Tg1 domain of testican-1
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
?
Elastin + H2O the enzyme shows distinctive preferences in degrading elastins from bovine neck ligament, aorta, and lung Homo sapiens ?
-
?