Literature summary for 3.4.22.15 extracted from

Bocock, J.P.; Edgell, C.J.; Marr, H.S.; Erickson, A.H.
Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L (2003), Eur. J. Biochem., 270, 4008-4015.

Search for more literature for 3.4.22.15

General Stability

General Stability	Organism
testican-1 stabilizes at neutral pH	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
testican-1	strong competitive inhibitor, inhibition is independent of its chondroitin sulfate chains and is effective at both pH 5.5 and pH 7.2, does not inhibit the structurally related lysosomal cysteine protease cathepsin B	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000007	-	testican-1	-	Homo sapiens

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Release 2023.1 (January 2023)