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Literature summary for 3.4.22.15 extracted from

  • Brinker, A.; Weber, E.; Stoll, D.; Voigt, J.; Muller, A.; Sewald, N.; Jung, G.; Wiesmuller, K.H.; Bohley, P.
    Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections (2000), Eur. J. Biochem., 267, 5085-5092.
    View publication on PubMed
Search for more literature for 3.4.22.15

Inhibitors

Inhibitors Comment Organism Structure
LFLRL 0.05 mM, 78% inhibition Homo sapiens
LFLTR-NH2 IC50: 0.0008 mM Homo sapiens
LKFTF 0.05 mM, 24% inhibition; 0.05 mM, 32% inhibition Homo sapiens
LKFTR 0.05 mM, 78% inhibition Homo sapiens
LKLFF 0.05 mM, 42% inhibition Homo sapiens
LKLFW 0.05 mM, 22% inhibition Homo sapiens
LKLLW 0.05 mM, 75% inhibition Homo sapiens
LLFLW 0.05 mM, 52% inhibition Homo sapiens
LLFRW 0.05 mM, 52% inhibition Homo sapiens
LLLLR 0.05 mM, 62% inhibition Homo sapiens
LLLLW 0.05 mM, 37% inhibition Homo sapiens
LLLRW 0.05 mM, 83% inhibition Homo sapiens
LLLTB 0.05 mM, 58% inhibition Homo sapiens
LLLTL 0.05 mM, 67% inhibition Homo sapiens
LLLTR-NH2 IC50: 0.0005 mM Homo sapiens
LLLTW 0.05 mM, 62% inhibition Homo sapiens
LLYLW 0.05 mM, 47% inhibition Homo sapiens
LLYTB 0.05 mM, 25% inhibition Homo sapiens
LLYTR 0.05 mM, 62% inhibition Homo sapiens
LLYTW 0.05 mM, 30% inhibition Homo sapiens
LRFTF 0.05 mM, 25% inhibition Homo sapiens
LRLLW 0.05 mM, 73% inhibition Homo sapiens
LWFFW 0.05 mM, 61% inhibition Homo sapiens
LWFRQ 0.05 mM, 20% inhibition Homo sapiens
LWFRW 0.05 mM, 20% inhibition Homo sapiens
LWLFL 0.05 mM, 73% inhibition Homo sapiens
LWLFW 0.05 mM, 31% inhibition Homo sapiens
LWLLW 0.05 mM, 52% inhibition Homo sapiens
RFLRW 0.05 mM, 21% inhibition Homo sapiens
RFLYR 0.05 mM, 64% inhibition Homo sapiens
RKLFL 0.05 mM, 79% inhibition Homo sapiens
RKLLW-NH2 IC50: 0.0006 mM Homo sapiens
RKLWD-NH2 IC50: 0.014 mM Homo sapiens
RKLWF 0.05 mM, 52% inhibition Homo sapiens
RKLWL-NH2 IC50: 0.0008 mM Homo sapiens
RKLWV 0.05 mM, 41% inhibition Homo sapiens
RLLLW 0.05 mM, 75% inhibition Homo sapiens
RLLYW 0.05 mM, 29% inhibition Homo sapiens
RRFYV 0.05 mM, 24% inhibition Homo sapiens
RRLTW 0.05 mM, 38% inhibition Homo sapiens
RRYLB 0.05 mM, 33% inhibition Homo sapiens
RWLTL 0.05 mM, 61% inhibition Homo sapiens
RWLYL 0.05 mM, 65% inhibition Homo sapiens
YFLLR 0.05 mM, 30% inhibition Homo sapiens
YFLTF 0.05 mM, 29% inhibition Homo sapiens
YKLLR 0.05 mM, 72% inhibition Homo sapiens
YLLFW 0.05 mM, 37% inhibition Homo sapiens
YLYLF 0.05 mM, 40% inhibition Homo sapiens
YWFTF 0.05 mM, 43% inhibition Homo sapiens
YWLLR 0.05 mM, 73% inhibition Homo sapiens
YWYYL 0.05 mM, 20% inhibition Homo sapiens
YYLLR 0.05 mM, 56% inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture medium of non-small-cell lung cancer cell line EPLC 32M1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00013
-
 RKLLW-NH2 pH 5.5, 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
 IC50: 0.0005 mM Homo sapiens LLLTR-NH2
0.0006
-
 IC50: 0.0006 mM Homo sapiens RKLLW-NH2
0.0008
-
 IC50: 0.0008 mM Homo sapiens LFLTR-NH2
0.0008
-
 IC50: 0.0008 mM Homo sapiens RKLWL-NH2
0.014
-
 IC50: 0.014 mM Homo sapiens RKLWD-NH2