Literature summary for 3.4.22.15 extracted from

Guay, J.; Falgueyret, J.P.; Ducret, A.; Percival, M.D.; Mancini, J.A.
Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides (2000), Eur. J. Biochem., 267, 6311-6318.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cathepsin K propeptide	-	Homo sapiens
cathepsin L propeptide	-	Homo sapiens
cathepsin S propeptide	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000012	-	cathepsin L propeptide	pH 5.5, room temperature	Homo sapiens
0.00000046	-	cathepsin S propeptide	pH 5.5, room temperature	Homo sapiens
0.0000026	-	cathepsin K propeptide	pH 5.5, room temperature	Homo sapiens

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Release 2023.1 (January 2023)