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Literature summary for 3.4.22.10 extracted from

  • Berggren, K.; Johansson, B.; Fex, T.; Kihlberg, J.; Bjoerck, L.; Luthman, K.
    Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant (2009), Bioorg. Med. Chem., 17, 3463-3470.
    View publication on PubMed
Search for more literature for 3.4.22.10

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Streptococcus pyogenes

Inhibitors

Inhibitors Comment Organism Structure
(S)-1-azido-2-tosylamino-hexane moderate inhibitor of IdeS Streptococcus pyogenes
(S)-1-azido-3-methyl-2-tosylamino-butane moderate inhibitor of IdeS Streptococcus pyogenes
(S)-1-azido-3-phenyl-2-tosylamino-propane moderate inhibitor of IdeS Streptococcus pyogenes
(S)-3-tosylamino-1-heptanal strong inhibitory activity Streptococcus pyogenes
(S)-3-tosylamino-heptane-1-nitrile the compound shows some inhibition of IdeS Streptococcus pyogenes
(S)-4-methyl-3-tosylamino-1-pentanal strong inhibitory activity Streptococcus pyogenes
(S)-4-phenyl-3-tosylamino-1-butanal strong inhibitory activity Streptococcus pyogenes
(S)-7-tert-butoxycarbonylamino-3-tosylamino-1-heptanal strong inhibitory activity Streptococcus pyogenes
iodoacetate irreversible inhibitor Streptococcus pyogenes
additional information IdeS is not inhibited by E-64, (S)-3-phenyl-2-tosylamino-1-propanol, (S)-2-tosylamino-1-hexanol, (S)-3-methyl-2-tosylamino-1-butanol, (S)-6-tert-butoxycarbonylamino-2-tosylamino-1-hexanol, (S)-6-amino-2-tosylamino-1-hexanol trifluoroacetic acid, (S)-3-phenyl-2-tosylamino-propyl-1-toluenesulfonate, (S)-2-tosylamino-hexyl-1-toluenesulfonate, (S)-3-methyl-2-tosylamino-butyl-1-toluenesulfonate, and (S)-6-tert-butoxycarbonylamino-2-tosylamino-hexyl-1-toluenesulfonate Streptococcus pyogenes
tosyl-L-lysine chloromethyl ketone irreversible inhibitor Streptococcus pyogenes
tosyl-L-phenylalanine chloromethyl ketone irreversible inhibitor Streptococcus pyogenes
Z-LVG-CHN2 irreversible inhibitor Streptococcus pyogenes

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 SDS-PAGE Streptococcus pyogenes

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptococcus pyogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
immunoglobulin G + H2O IdeS cleaves IgG by hydrolyzing the peptide bond between two glycine residues in the hinge region of IgG, generating one F(ab')2 fragment and two 1/2 Fc fragments Streptococcus pyogenes F(ab')2 fragment + 1/2 Fc fragments
-
 ?

Synonyms

Synonyms Comment Organism
IdeS
-
 Streptococcus pyogenes
IgG-degrading enzyme of Streptococcus pyogenes
-
 Streptococcus pyogenes