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Literature summary for 3.4.22.10 extracted from

  • Cole, J.N.; Aquilina, J.A.; Hains, P.G.; Henningham, A.; Sriprakash, K.S.; Caparon, M.G.; Nizet, V.; Kotb, M.; Cordwell, S.J.; Djordjevic, S.P.; Walker, M.J.
    Role of group A Streptococcus HtrA in the maturation of SpeB protease (2007), Proteomics, 7, 4488-4498.
    View publication on PubMed
Search for more literature for 3.4.22.10

Activating Compound

Activating Compound Comment Organism Structure
additional information serine protease high-temperature requirement A plays an indirect role in the maturation process of SpeB Streptococcus pyogenes M1 GAS

Inhibitors

Inhibitors Comment Organism Structure
N-[N-(L-3-transcarboxyirane-2-carbonyl)-L-leucyl]agmatine
-
 Streptococcus pyogenes M1 GAS

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
 mature SpeB, SDS-PAGE Streptococcus pyogenes M1 GAS
40000
-
 precursor proSpeB, SDS-PAGE Streptococcus pyogenes M1 GAS

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes M1 GAS P0C0J1 precursor
-
Streptococcus pyogenes M1 GAS HSC5 P0C0J1 precursor
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
 Streptococcus pyogenes M1 GAS ?
-
 ?
casein + H2O
-
 Streptococcus pyogenes M1 GAS HSC5 ?
-
 ?
proSpeB + H2O autoactivation Streptococcus pyogenes M1 GAS SpeB + ?
-
 ?
proSpeB + H2O autoactivation Streptococcus pyogenes M1 GAS HSC5 SpeB + ?
-
 ?

Synonyms

Synonyms Comment Organism
SpeB
-
 Streptococcus pyogenes M1 GAS
streptococcal pyrogenic exotoxin B
-
 Streptococcus pyogenes M1 GAS