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Literature summary for 3.4.22.10 extracted from
- Streptococcal pyrogenic exotoxin B causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of group A streptococcus (2006), Med. Microbiol. Immunol., 195, 55-63.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | incubation with human alveolar basal epithelial A549 cells induce enzyme expression | Streptococcus pyogenes |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene speB, native expression pattern, expression of wild-type and mutant enzymes in Escherichia coli strain DH5alpha | Streptococcus pyogenes |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C192S | inactive mutant | Streptococcus pyogenes |
| additional information | construction of an isogenic inactive mutant strain M6 | Streptococcus pyogenes |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Streptococcus pyogenes | the enzyme inactivates the metabolic activity of polymorphonuclear cells, the enzyme causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of group A Streptococcus, it is essential for bacterial survival in blood, mechanism, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptococcus pyogenes | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme inactivates the metabolic activity of polymorphonuclear cells, the enzyme causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of group A Streptococcus, it is essential for bacterial survival in blood, mechanism, overview | Streptococcus pyogenes | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SpeB | - |
Streptococcus pyogenes |
| streptococcal pyrogenic exotoxin B | - |
Streptococcus pyogenes |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Streptococcus pyogenes |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Streptococcus pyogenes |
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