BRENDA - Enzyme Database show
show all sequences of 3.4.22.10

IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G

von Pawel-Rammingen, U.; Johansson, B.P.; Bjorck, L.; EMBO J. 21, 1607-1615 (2002)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Streptococcus pyogenes
thus, although IgG might by a substrate for SpeB under certain environmental conditions, it seems unlikely that SpeB is part of the first line of defense against specific antibodies. Even though SpeB might not be directly involved in the attenuation of the adaptive immune response, its proteolytic activity towards streptococcal surface proteins, including IgG-binding proteins and the streptococcal C5a peptidase, could certainly be important for the modulation of the complement system
?
-
Streptococcus pyogenes
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Streptococcus pyogenes
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
proteolytic modification
SpeB is secreted as a 40000 Da proenzyme that is converted into a mature 28000 Da active proteinase by autocatalytic cleavage
Streptococcus pyogenes
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
IgA + H2O
degradation of the carboxy-terminal part of the heavy chain
650988
Streptococcus pyogenes
?
-
650988
Streptococcus pyogenes
?
IgD + H2O
degradation of the carboxy-terminal part of the heavy chain
650988
Streptococcus pyogenes
?
-
650988
Streptococcus pyogenes
?
IgE + H2O
degradation of the carboxy-terminal part of the heavy chain
650988
Streptococcus pyogenes
?
-
650988
Streptococcus pyogenes
?
IgG + H2O
the enzyme cleaves IgG in the flexible hinge region of the IgG heavy chain, generating two Fab fragments and Fc fragment. SpeB cleaves the heavy chain at a defined site between glycine residues 236 and 237
650988
Streptococcus pyogenes
Fab fragment + Gc fragments
-
650988
Streptococcus pyogenes
?
IgM + H2O
degradation of the carboxy-terminal part of the heavy chain
650988
Streptococcus pyogenes
?
-
650988
Streptococcus pyogenes
?
additional information
thus, although IgG might by a substrate for SpeB under certain environmental conditions, it seems unlikely that SpeB is part of the first line of defense against specific antibodies. Even though SpeB might not be directly involved in the attenuation of the adaptive immune response, its proteolytic activity towards streptococcal surface proteins, including IgG-binding proteins and the streptococcal C5a peptidase, could certainly be important for the modulation of the complement system
650988
Streptococcus pyogenes
?
-
650988
Streptococcus pyogenes
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Streptococcus pyogenes
thus, although IgG might by a substrate for SpeB under certain environmental conditions, it seems unlikely that SpeB is part of the first line of defense against specific antibodies. Even though SpeB might not be directly involved in the attenuation of the adaptive immune response, its proteolytic activity towards streptococcal surface proteins, including IgG-binding proteins and the streptococcal C5a peptidase, could certainly be important for the modulation of the complement system
?
-
Streptococcus pyogenes
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
proteolytic modification
SpeB is secreted as a 40000 Da proenzyme that is converted into a mature 28000 Da active proteinase by autocatalytic cleavage
Streptococcus pyogenes
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
IgA + H2O
degradation of the carboxy-terminal part of the heavy chain
650988
Streptococcus pyogenes
?
-
650988
Streptococcus pyogenes
?
IgD + H2O
degradation of the carboxy-terminal part of the heavy chain
650988
Streptococcus pyogenes
?
-
650988
Streptococcus pyogenes
?
IgE + H2O
degradation of the carboxy-terminal part of the heavy chain
650988
Streptococcus pyogenes
?
-
650988
Streptococcus pyogenes
?
IgG + H2O
the enzyme cleaves IgG in the flexible hinge region of the IgG heavy chain, generating two Fab fragments and Fc fragment. SpeB cleaves the heavy chain at a defined site between glycine residues 236 and 237
650988
Streptococcus pyogenes
Fab fragment + Gc fragments
-
650988
Streptococcus pyogenes
?
IgM + H2O
degradation of the carboxy-terminal part of the heavy chain
650988
Streptococcus pyogenes
?
-
650988
Streptococcus pyogenes
?
additional information
thus, although IgG might by a substrate for SpeB under certain environmental conditions, it seems unlikely that SpeB is part of the first line of defense against specific antibodies. Even though SpeB might not be directly involved in the attenuation of the adaptive immune response, its proteolytic activity towards streptococcal surface proteins, including IgG-binding proteins and the streptococcal C5a peptidase, could certainly be important for the modulation of the complement system
650988
Streptococcus pyogenes
?
-
650988
Streptococcus pyogenes
?
Other publictions for EC 3.4.22.10
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733967
Chella Krishnan
Metal-mediated modulation of s ...
Streptococcus pyogenes
Infect. Immun.
82
2992-3001
2014
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733964
Persson
The streptococcal cysteine pro ...
Streptococcus pyogenes
Infect. Immun.
81
2236-2241
2013
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4
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1
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734212
Sumitomo
Group A streptococcal cysteine ...
Streptococcus pyogenes
J. Biol. Chem.
288
13317-13324
2013
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1
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734185
Gonzalez-Paez
Ultrahigh and high resolution ...
Streptococcus pyogenes, Streptococcus pyogenes ATCC 10782
J. Biol. Chem.
287
24412-24426
2012
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1
9
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2
10
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10
1
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7
7
717218
Meinert Niclasen
Streptococcal pyogenic exotoxi ...
Streptococcus pyogenes, Streptococcus pyogenes Alab49, Streptococcus pyogenes AP1
Biochem. J.
434
123-132
2011
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8
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717311
Nelson
Cysteine proteinase SpeB from ...
Streptococcus pyogenes
Biol. Chem.
392
1077-1088
2011
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31
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1
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718299
Connolly
Srv mediated dispersal of stre ...
Streptococcus sp., Streptococcus sp. MGAS315, Streptococcus sp. RGAS053
PLoS ONE
6
e28640
2011
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718127
Kurupati
Chemokine-cleaving Streptococc ...
Streptococcus pyogenes, Streptococcus pyogenes H292
Mol. Microbiol.
76
1387-1397
2010
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11
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11
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698880
Wang
Solution structure and backbon ...
Streptococcus pyogenes
J. Biol. Chem.
284
10957-10967
2009
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9
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707720
Berggren
Synthesis and biological evalu ...
Streptococcus pyogenes
Bioorg. Med. Chem.
17
3463-3470
2009
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1
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13
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680145
Kuo
Degradation of complement 3 by ...
Streptococcus pyogenes
Infect. Immun.
76
1163-1169
2008
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1
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1
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2
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680146
Tsai
Streptococcal pyrogenic exotox ...
Streptococcus pyogenes
Infect. Immun.
76
1349-1357
2008
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1
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2
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700243
Soederberg
The streptococcal protease Ide ...
Streptococcus pyogenes
Mol. Immunol.
45
3347-3353
2008
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1
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679955
Kuo
Abrogation of streptococcal py ...
Streptococcus pyogenes
Food Chem. Toxicol.
45
278-285
2007
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681702
Luo
Streptococcal pyrogenic exotox ...
Streptococcus pyogenes
Kidney Int.
72
716-724
2007
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1
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6
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682803
Cole
Role of group A Streptococcus ...
Streptococcus pyogenes M1 GAS, Streptococcus pyogenes M1 GAS HSC5
Proteomics
7
4488-4498
2007
1
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667426
Tsao
Streptococcal pyrogenic exotox ...
Streptococcus pyogenes
Biochem. Biophys. Res. Commun.
339
779-784
2006
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670124
Chiang-Ni
Streptococcal pyrogenic exotox ...
Streptococcus pyogenes
Med. Microbiol. Immunol.
195
55-63
2006
1
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680712
Nooh
Streptococcal mitogenic exotox ...
Streptococcus pyogenes
J. Biol. Chem.
281
35281-35288
2006
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667311
Anderson
The pro-sequence domain of str ...
Streptococcus pyogenes
Arch. Biochem. Biophys.
436
297-306
2005
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668918
Wei
Impact of the SpeB protease on ...
Streptococcus pyogenes
Infect. Immun.
73
2040-2050
2005
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670312
Kagawa
SpeB-Spi: a novel protease-inh ...
Streptococcus pyogenes, Streptococcus pyogenes B220
Mol. Microbiol.
57
650-666
2005
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1
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1
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7
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Cleavage of antigen-bound immu ...
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2003
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Crystal structure of the zymog ...
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11
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1
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81462
Stockbauer
A natural variant of the cyste ...
Streptococcus sp.
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1999
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1
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81470
Matsuka
Fibrinogen cleavage by the Str ...
Streptococcus pyogenes
Infect. Immun.
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1999
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1
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2
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81471
Lukomski
Extracellular cysteine proteas ...
Streptococcus pyogenes
Infect. Immun.
67
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1999
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1
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81472
Eriksson
The superantigenic activity of ...
Streptococcus sp., Streptococcus sp. T10BW
FEMS Immunol. Med. Microbiol.
25
355-363
1999
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1
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2
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81452
Ashbaugh
Molecular analysis of the role ...
Streptococcus sp.
J. Clin. Invest.
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550-560
1998
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1
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1
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81469
Tsai
Effect of group A streptococca ...
Streptococcus pyogenes
Infect. Immun.
66
1460-1466
1998
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1
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1
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2
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81463
Burns
Structure-function and pathoge ...
Streptococcus pyogenes
Adv. Exp. Med. Biol.
418
589-592
1997
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81468
Chaussee
Temporal production of strepto ...
Streptococcus pyogenes
Infect. Immun.
65
1956-1959
1997
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1
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81466
Burns
Activation of a 66-kilodalton ...
Streptococcus pyogenes
Infect. Immun.
64
4744-4750
1996
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1
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81467
Herwald
Streptococcal cysteine protein ...
Streptococcus pyogenes
J. Exp. Med.
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1996
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2
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81456
Berge
Streptococcal cysteine protein ...
Streptococcus pyogenes
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270
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1995
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4
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81454
Green
Peptidyl diazomethyl ketones a ...
Streptococcus sp.
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1981
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7
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7
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81455
Kortt
Primary structure of streptoco ...
Streptococcus sp.
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251
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81457
Tai
Primary structure of streptoco ...
Streptococcus sp.
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251
1955-1959
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81458
Kortt
On the mechanism of action of ...
Streptococcus sp.
Biochemistry
12
320-327
1973
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2
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81459
Kortt
On the mechanism of action of ...
Streptococcus sp.
Biochemistry
12
328-337
1973
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8
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2
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7
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8
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10
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7
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81460
Kortt
On the mechanism of action of ...
Streptococcus sp.
Biochemistry
12
338-345
1973
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3
6
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2
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6
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2
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6
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81451
Liu
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Streptococcal proteinase ...
Streptococcus sp.
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
3
609-647
1971
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11
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1
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81461
Elliott
-
Streptococcal proteinase ...
Streptococcus sp.
Methods Enzymol.
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1970
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3
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81465
Gerwin
On the specificity of streptoc ...
Streptococcus sp.
J. Biol. Chem.
241
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1966
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81464
Liu
Streptococcal proteinase: the ...
Streptococcus pyogenes
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