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Literature summary for 3.4.22.1 extracted from

  • Mijanovic, O.; Brankovic, A.; Panin, A.N.; Savchuk, S.; Timashev, P.; Ulasov, I.; Lesniak, M.S.
    Cathepsin B A sellsword of cancer progression (2019), Cancer Lett., 449, 207-214 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Application

Application Comment Organism
drug development cathepsin B is a target for anti-cancer therapy. RNA interference oligonucleotide shRNA-CTSB2 is the most efficient inhibition of cathepsin B at both mRNA and protein levels and results in suppressing endometrial cancer growth and development in vivo Homo sapiens
medicine cathepsin B is a target for anti-cancer therapy. RNA interference oligonucleotide shRNA-CTSB2 is the most efficient inhibition of cathepsin B at both mRNA and protein levels and results in suppressing endometrial cancer growth and development in vivo Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-(N-benzyloxycarbonylphenylalanylamido)-DL-1-fluoro-2-butanone irreversible covalent inhibitor Homo sapiens
ankyrin repeat protein i.e. DARPin 8h6 Homo sapiens
benzyloxycarbonyl-L-phenylalanyl-L-phenylalanyl diazomethyl ketone irreversible covalent inhibitor Homo sapiens
benzyloxycarbonyl-phenylalanyl diazomethyl ketone irreversible covalent inhibitor Homo sapiens
Bz-Phe-Arg-CH2F irreversible covalent inhibitor Homo sapiens
CA-074 i.-e. [L-3-trans-(propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline and its derivates, irreversible covalent inhibitor Homo sapiens
E-64 irreversible covalent inhibitor Homo sapiens
E64d i.e. loxistatin, irreversible covalent inhibitor Homo sapiens
Miraziridine A irreversible covalent inhibitor Homo sapiens
additional information concanamycin A is an indirect inhibitor by specific inhibiton of VATPase Homo sapiens
N-Acetyl-Leu-Leu-methional reversible inhibitor Homo sapiens
peptidyl cyclopropenone reversible inhibitor Homo sapiens
RNA interference oligonucleotide shRNA-CTSB2 most efficient inhibition of cathepsin B at both mRNA and protein levels and results in suppressing endometrial cancer growth and development in vivo Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
lysosome stress stimulated secretion from the lysosomes Homo sapiens 5764
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P07858
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification cathepsin B is first expressed as a 44 kDa inactive precursor which then undergoes maturation to produce a 33 kDa lysosome enzyme later converted to a final active form composed of two (24 and 5 kDa) subunits Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
chondrocyte
-
 Homo sapiens
-
colonic adenocarcinoma cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
rheumatoid arthritis disease specific synovial tissue
-
 Homo sapiens
-
T/C-28a2 cell
-
 Homo sapiens
-

General Information

General Information Comment Organism
physiological function the main functions are the turnover of cellular proteins, the regulation of angiogenesis, invasion, tumor proliferation and immune resistance, neurogenesis, cellular differentiation and tumor response to hypoxia. Cathepsin B plays a protective role by degrading excessive amounts of misfolded protein inside the cell. In humans, the levels of cathepsin B correlates with hippocampal-dependent memory functions and can be increased by physical exercise. The decrease in the rate of neurogenesis in Alzheimer's disease can be secondary to the accumulation of the critical Alzheimer's disease proteins, which can be induced by inhibition of cathepsin B and the consequent the lysosomal dysfunction. The expression of cathepsin B is elevated in many, but not all, cancers Homo sapiens