Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,1'-[[3-(5-nitroquinolin-8-yl)furan-2,5-diyl]dibenzene-4,1-diyl]diethanone | - |
Homo sapiens | |
1-[4-[3-(5-nitroquinolin-8-yl)furan-2-yl]phenyl]ethan-1-one | - |
Homo sapiens | |
2-methyl-5-nitroquinolin-8-ol | - |
Homo sapiens | |
4-methoxy-3-(3-methoxypropoxy)-1-(5-nitroquinolin-8-yl)pyridin-1-ium | - |
Homo sapiens | |
8-hydroxy-5-nitroquinoline-2-carbonitrile | - |
Homo sapiens | |
N-(1-cyanocyclopropyl)-8-hydroxy-5-nitroquinoline-7-carboxamide | - |
Homo sapiens | |
N-(cyanomethyl)-5-nitroquinoline-8-carboxamide | - |
Homo sapiens | |
N-(cyanomethyl)-8-hydroxy-5,7-dinitroquinoline-2-carboxamide | - |
Homo sapiens | |
N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-7-carboxamide | - |
Homo sapiens | |
N-benzyl-N-(cyanomethyl)-8-hydroxy-5,7-dinitroquinoline-2-carboxamide | - |
Homo sapiens | |
N-benzyl-N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-2-carboxamide | - |
Homo sapiens | |
N-benzyl-N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-7-carboxamide | - |
Homo sapiens | |
N-[[1-(1,3-benzothiazol-2-yl)piperidin-3-yl]methyl]-8-hydroxy-5-nitroquinoline-7-carboxamide | - |
Homo sapiens | |
N-[[1-(1,3-benzoxazol-2-yl)piperidin-3-yl]methyl]-8-hydroxy-5-nitroquinoline-7-carboxamide | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07858 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH + H2O | exopeptidase activity | Homo sapiens | ? | - |
? | |
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O | endopeptidase activity | Homo sapiens | benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.035 | - |
N-benzyl-N-(cyanomethyl)-8-hydroxy-5,7-dinitroquinoline-2-carboxamide | substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.118 | - |
4-methoxy-3-(3-methoxypropoxy)-1-(5-nitroquinolin-8-yl)pyridin-1-ium | substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.128 | - |
N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-7-carboxamide | substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.142 | - |
8-hydroxy-5-nitroquinoline-2-carbonitrile | substrate: benzyloxycarbonyl-Arg-Arg-AMC, endopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.156 | - |
N-benzyl-N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-2-carboxamide | substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.16 | - |
N-(cyanomethyl)-8-hydroxy-5,7-dinitroquinoline-2-carboxamide | substrate: benzyloxycarbonyl-Arg-Arg-AMC, endopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.181 | - |
2-methyl-5-nitroquinolin-8-ol | substrate: benzyloxycarbonyl-Arg-Arg-AMC, endopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.182 | - |
N-benzyl-N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-7-carboxamide | substrate: benzyloxycarbonyl-Arg-Arg-AMC, endopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.185 | - |
N-benzyl-N-(cyanomethyl)-8-hydroxy-5-nitroquinoline-7-carboxamide | substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.185 | - |
N-(1-cyanocyclopropyl)-8-hydroxy-5-nitroquinoline-7-carboxamide | substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.19 | - |
N-(cyanomethyl)-5-nitroquinoline-8-carboxamide | substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.201 | - |
N-(cyanomethyl)-8-hydroxy-5,7-dinitroquinoline-2-carboxamide | substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.214 | - |
8-hydroxy-5-nitroquinoline-2-carbonitrile | substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.24 | - |
N-(cyanomethyl)-5-nitroquinoline-8-carboxamide | substrate: benzyloxycarbonyl-Arg-Arg-AMC, endopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.323 | - |
4-methoxy-3-(3-methoxypropoxy)-1-(5-nitroquinolin-8-yl)pyridin-1-ium | substrate: benzyloxycarbonyl-Arg-Arg-AMC, endopeptidase activity, pH and temperature not specified in the publication | Homo sapiens | |
0.469 | - |
2-methyl-5-nitroquinolin-8-ol | substrate: 2-aminobenzoy-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH, exopeptidase activity, pH and temperature not specified in the publication | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in intracellular proteolysis within lysosomes. Increased activity and expression are strongly associated with many pathological processes, including cancers | Homo sapiens |