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Literature summary for 3.4.22.1 extracted from

  • Bian, B.; Mongrain, S.; Cagnol, S.; Langlois, M.; Boulanger, J.; Bernatchez, G.; Carrier, J.; Boudreau, F.; Rivard, N.
    Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis (2015), Mol. Carcinog., 55, 671-687.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
CA074 treatment of colorectal cancer cells cells with the cathepsin B inhibitor Ca074 leads to invasiveness of human CRC cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P07858
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
Homo sapiens
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colorectal cancer cell line
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
cathepsin B
-
Homo sapiens

General Information

General Information Comment Organism
malfunction Cathepsin B silencing by RNAi in human colorectal cancer (CRC) cells inhibits their growth in soft agar, as well as their invasion capacity, tumoral expansion, and metastatic spread in immunodeficient mice Homo sapiens
malfunction higher levels of the cell cycle inhibitor p27Kip1 are observed in cathepsin B-deficient tumors as well as an increase in cyclin B1 Homo sapiens
physiological function extracellular cathepsin B is involved in cell invasion whereas intracellular cathepsin B controls tumoral properties of colorectal cancer cells Homo sapiens