Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA074 | treatment of colorectal cancer cells cells with the cathepsin B inhibitor Ca074 leads to invasiveness of human CRC cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07858 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | - |
Homo sapiens | - |
colorectal cancer cell line | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
cathepsin B | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | Cathepsin B silencing by RNAi in human colorectal cancer (CRC) cells inhibits their growth in soft agar, as well as their invasion capacity, tumoral expansion, and metastatic spread in immunodeficient mice | Homo sapiens |
malfunction | higher levels of the cell cycle inhibitor p27Kip1 are observed in cathepsin B-deficient tumors as well as an increase in cyclin B1 | Homo sapiens |
physiological function | extracellular cathepsin B is involved in cell invasion whereas intracellular cathepsin B controls tumoral properties of colorectal cancer cells | Homo sapiens |