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Literature summary for 3.4.22.1 extracted from

  • Wang, C.; Sun, B.; Zhou, Y.; Grubb, A.; Gan, L.
    Cathepsin B degrades amyloid-beta in mice expressing wild-type human amyloid precursor protein (2012), J. Biol. Chem., 287, 39834-39841.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Inhibitors

Inhibitors Comment Organism Structure
CysC natural inhibitor of CatB. CysC deletion in knockout mice leads to an enhanced CatB activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
CatB
-
 Mus musculus
cathepsin B
-
 Mus musculus

General Information

General Information Comment Organism
malfunction CysC deletion in knockout mice leads to an enhanced CatB activity Mus musculus
malfunction enhancing CatB activity by CysC deletion significantly lowers total amyloid-betaand amyloid-beta42 levels in human amyloid precursor protein wild-type mice, whereas CatB deletion increases amyloidbeta levels Mus musculus
malfunction transgenic mice are generated overexpressing CatB under the control of a neuron-specific enolase promoter: Enhancing neuronal CatB activity in human amyloid precursor protein wild-type mice significantly lowers amyloidbeta42 levels Mus musculus