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Literature summary for 3.4.22.1 extracted from
- Molecular characterization of the cathepsin B of turbot (Scophthalmus maximus) (2015), Fish Physiol. Biochem., 41, 473-483.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Scophthalmus maximus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C107S | mutant shows a reduced protease activity | Scophthalmus maximus |
| H277A | mutant shows a reduced protease activity | Scophthalmus maximus |
| N297A | mutant shows a very high reduced protease activity | Scophthalmus maximus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36000 | - |
calculated from cDNA | Scophthalmus maximus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Scophthalmus maximus | Q27HX3 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Scophthalmus maximus | - |
| brain | - |
Scophthalmus maximus | - |
| gill | - |
Scophthalmus maximus | - |
| gut | - |
Scophthalmus maximus | - |
| heart | - |
Scophthalmus maximus | - |
| kidney | - |
Scophthalmus maximus | - |
| liver | - |
Scophthalmus maximus | - |
| muscle | - |
Scophthalmus maximus | - |
| spleen | highest expression in liver | Scophthalmus maximus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CBZ-L-Arg-L-Arg-4-nitroanilide + H2O | - |
Scophthalmus maximus | L-Arg-L-Arg + 4-nitroaniline | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cathepsin B | - |
Scophthalmus maximus |
| SmCatB | - |
Scophthalmus maximus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
assay at | Scophthalmus maximus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | 55 | 60% of activity maintained | Scophthalmus maximus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
assay at | Scophthalmus maximus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 7 | 60% of activity maintained | Scophthalmus maximus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Scophthalmus maximus | lowest expression in liver an brain | down |
| Scophthalmus maximus | expression is upregulated by bacterial infection in a time-dependent manner | up |
| Scophthalmus maximus | highest expression in liver | up |
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