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Literature summary for 3.4.22.1 extracted from

  • Bien, S.; Rimmbach, C.; Neumann, H.; Niessen, J.; Reimer, E.; Ritter, C.A.; Rosskopf, D.; Cinatl, J.; Michaelis, M.; Schroeder, H.W.; Kroemer, H.K.
    Doxorubicin-induced cell death requires cathepsin B in HeLa cells (2010), Biochem. Pharmacol., 80, 1466-1477.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CA074Me cathepsin B specific inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
caspase 1 precursor + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
LN-18 cell
-
Homo sapiens
-
PaTuO-2 cell
-
Homo sapiens
-
U-87MG cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
caspase 1 precursor + H2O
-
Homo sapiens ?
-
?
L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
CatB
-
Homo sapiens

General Information

General Information Comment Organism
malfunction both caspase 3 activation and PARP cleavage are significantly reduced in cells lacking cathepsin B. Mitochondrial membrane permeabilization as well as the release of cytochrome C and AIF from mitochondria into cytosol induced by doxorubicin are significantly diminished in cathepsin B suppressed cells. Cell viability following doxorubicin is significantly elevated in cells with cathepsin B silencing Homo sapiens
physiological function cathepsin B plays a role in doxorubicin-induced cell death Homo sapiens