Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA074Me | cathepsin B specific inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
caspase 1 precursor + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
LN-18 cell | - |
Homo sapiens | - |
PaTuO-2 cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
caspase 1 precursor + H2O | - |
Homo sapiens | ? | - |
? | |
L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | L-Arg-L-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CatB | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | both caspase 3 activation and PARP cleavage are significantly reduced in cells lacking cathepsin B. Mitochondrial membrane permeabilization as well as the release of cytochrome C and AIF from mitochondria into cytosol induced by doxorubicin are significantly diminished in cathepsin B suppressed cells. Cell viability following doxorubicin is significantly elevated in cells with cathepsin B silencing | Homo sapiens |
physiological function | cathepsin B plays a role in doxorubicin-induced cell death | Homo sapiens |