Protein Variants | Comment | Organism |
---|---|---|
additional information | CatB silencing with siRNA in U87-MG cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetic acid | complete inhibition at 1 mM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioblastoma cell | expression of cathepsins B, L and S gradually increases in the progression from benign astrocytoma to the malignant glioblastoma | Homo sapiens | - |
SNB-19 cell | a glioblastoma cell line | Homo sapiens | - |
U-87MG cell | a glioblastoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CatB | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression of cathepsins B, L and S gradually increases in the progression from benign astrocytoma to the malignant glioblastoma | up |
General Information | Comment | Organism |
---|---|---|
malfunction | the activity of CatB, but not of CatL or CatS, is relevant to glioblastoma invasion, role of cathepsin B in glioma invasion by in vitro 3D spheroids migration modelling of in vivo glioma growth and invasion, overview | Homo sapiens |