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Literature summary for 3.4.22.1 extracted from

  • Oztay, F.; Gezginci-Oktayoglu, S.; Bayrak, B.B.; Yanardag, R.; Bolkent, S.
    Cathepsin B inhibition improves lung injury associated to D-galactosamine/tumor necrosis factor-alpha-induced liver injury in mice (2010), Mol. Cell. Biochem., 333, 65-72.
    View publication on PubMed
Search for more literature for 3.4.22.1

Application

Application Comment Organism
pharmacology use of benzyloxycarbonyl-L-phenylalanyl-alanine-fluoromethylketone for inhibition of cathepsin-B seems a viable therapeutic strategy in TNF-alpha-mediated acute lung damage Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-L-phenylalanyl-alanine-fluoromethylketone inhibits cathepsin B, treatment stimulates proliferation of type-II pneumocytes and improves degenerative alterations in injured lung occurring with liver injury induced by D-GalN/TNF-alpha, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome cathepsin B is expressed ubiquitously and represents the major portion of lysosomal enzymes Mus musculus 5764
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Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male BALB/c mice
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Source Tissue

Source Tissue Comment Organism Textmining
bronchial epithelial cell
-
 Mus musculus
-
fibroblast
-
 Mus musculus
-
liver
-
 Mus musculus
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lung mesothelial cells and fibroblasts Mus musculus
-
mesothelium
-
 Mus musculus
-
additional information cathepsin B is expressed ubiquitously and represents the major portion of lysosomal enzymes Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
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 Mus musculus N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?

General Information

General Information Comment Organism
metabolism cathepsin B is involved in TNF-alpha-induced signal transduction pathways in lung cells Mus musculus
physiological function cathepsin B acts as the main executor of caspase dependent or independent cell death in major organs including the liver, kidney, and lungs Mus musculus