Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lipopolysaccharide | activates a Cat-B-dependent programmed death response in endothelial cells that is independent of both myeloid differentiation factor 88 and Toll-like receptor-associated interferon-inducing factor, is blocked by both Fas-associated death domain protein and phosphatidylinositol 3 kinase. Activates both caspase- and Cat B-dependent death pathways in presence of phosphatidylinositol 3 kinase inhibitor LY294002 or the inflammatory cytokine interferon-gamma | Homo sapiens | |
additional information | knockdown of cellular FLICE inhibitory protein potentiates the caspase-dependent pathway but does not activate the Cat B-dependent death response. Also knockdown of either myeloid differentiation factor 88 or Toll-like receptor-associated interferon-inducing factor expression does not affect the LPS-triggered Cat B death response in Fas-associated death domain protein-deficient human umbilical vein endothelial cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074-Me | Cat B-selective inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | human umbilical vein endothelial cells, HUVECs | Homo sapiens | - |
umbilical vein | human umbilical vein endothelial cells, HUVECs | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
cat B | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | based on the use of proteinase inhibitors, cell death changes from being principally caspase-dependent to being principally cathepsin B-dependent, overview | Homo sapiens |