Activating Compound | Comment | Organism | Structure |
---|---|---|---|
emodin | i.e. 1,3,8-trihydroxy-6-methylanthraquinone, emodin at apoptosis-inducing concentrations causes expression and activation of cathepsin B protein | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression analysis by real-time RT-PCR | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074 | a cathepsin B inhibitor significantly attenuates the ratio of hypodiploid and apoptotic cells, partially blocks caspase 3 activation and inhibits reduction of cell viability induced by emodin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | participation of cathepsin B in emodin-induced apoptosis in HK-2 cells, enzyme inhibition by Ca-074 causes significant attenuation the ratio of hypodiploid and apoptotic cells, partially blockage of caspase 3 activation and inhibition of reduction of cell viability induced by emodin, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HK-2 cell | a human proximal tubular epithelial cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin hydrochloride + H2O | - |
Homo sapiens | carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin hydrochloride | - |
? | |
additional information | participation of cathepsin B in emodin-induced apoptosis in HK-2 cells, enzyme inhibition by Ca-074 causes significant attenuation the ratio of hypodiploid and apoptotic cells, partially blockage of caspase 3 activation and inhibition of reduction of cell viability induced by emodin, overview | Homo sapiens | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
assay at | Homo sapiens |