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Literature summary for 3.4.22.1 extracted from

  • Wang, C.; Jiang, Z.; Yao, J.; Wu, X.; Sun, L.; Liu, C.; Duan, W.; Yan, M.; Sun, L.; Liu, J.; Zhang, L.
    Participation of cathepsin B in emodin-induced apoptosis in HK-2 cells (2008), Toxicol. Lett., 181, 196-204.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
emodin i.e. 1,3,8-trihydroxy-6-methylanthraquinone, emodin at apoptosis-inducing concentrations causes expression and activation of cathepsin B protein Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis by real-time RT-PCR Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CA-074 a cathepsin B inhibitor significantly attenuates the ratio of hypodiploid and apoptotic cells, partially blocks caspase 3 activation and inhibits reduction of cell viability induced by emodin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens participation of cathepsin B in emodin-induced apoptosis in HK-2 cells, enzyme inhibition by Ca-074 causes significant attenuation the ratio of hypodiploid and apoptotic cells, partially blockage of caspase 3 activation and inhibition of reduction of cell viability induced by emodin, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HK-2 cell a human proximal tubular epithelial cell line Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin hydrochloride + H2O
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Homo sapiens carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin hydrochloride
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?
additional information participation of cathepsin B in emodin-induced apoptosis in HK-2 cells, enzyme inhibition by Ca-074 causes significant attenuation the ratio of hypodiploid and apoptotic cells, partially blockage of caspase 3 activation and inhibition of reduction of cell viability induced by emodin, overview Homo sapiens ?
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?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
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assay at Homo sapiens