Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA074 | an irreversible CB inhibitor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is released by activated microglia accumulating in the granule cell layer of the lingual and central lobe | Rattus norvegicus | - |
- |
lysosome | - |
Rattus norvegicus | 5764 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
monomethylmercuric cation | treatment leads to increased cathepsin B mainly in activated microglia which accumulate in the granule cell layer of the cerebellum | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | cathepsin B secreted by activated microglia is closely associated with the MeHg-induced severe pyknotic changes of the cerebellar granule cells, overview. Cathepsin B is involved in apoptotic processes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
cerebellum | - |
Rattus norvegicus | - |
microglia | from the granule cell layer of the lingual and central lobe | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | cathepsin B secreted by activated microglia is closely associated with the MeHg-induced severe pyknotic changes of the cerebellar granule cells, overview. Cathepsin B is involved in apoptotic processes | Rattus norvegicus | ? | - |
? |