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Literature summary for 3.4.22.1 extracted from
- Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages (2008), J. Immunol., 181, 690-697.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | bone marrow-derived macrophages from cathepsin B-deficient C57BL/6 mice and macrophages treated with the small interfering RNA against cathepsin B secret significantly less TNF-alpha than wild-type or nontreated macrophages | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CA074Me | - |
Homo sapiens |  |
| cathepsin B inhibitor III | i.e. L-trans.epoxysuccinyl(propylamide)-Ile-Pro or 1-[3-methyl-2-[[3-(propylcarbamoyl)oxirane]-2-carbonyl]amino]pentanoylpyrrolidine-2-carboxylic acid | Mus musculus | |
| cathepsin B inhibitor IV | i.e. CA074me or methyl 1-[3-methyl-2-[[3-(propylcarbamoyl)oxirane]-2-carbonyl]amino]pentanoylpyrrolidine-2-carboxylate, bone marrow-derived macrophages treated with the cathepsin B-specific chemical inhibitor CA074 methyl ester secret significantly less TNF-alpha than wild-type or nontreated macrophages | Mus musculus | |
| additional information | the inhibition of cathepsin B causes accumulation of 26-kDa pro-TNF-containing vesicles | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Mus musculus | 5764 | - |
| lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages | ? | - |
? | |
| additional information | Homo sapiens | cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages | ? | - |
? | |
| additional information | Mus musculus C57BL/6 | cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages | ? | - |
? | |
| TNF-alpha + H2O | Homo sapiens | cathepsin B is required for optimal posttranslational processing of TNF-alpha | ? | - |
? | |
| TNF-alpha + H2O | Mus musculus | cathepsin B is required for optimal posttranslational processing of TNF-alpha in response to the bacterial cell wall component lipopolysacchrides | ? | - |
? | |
| TNF-alpha + H2O | Mus musculus C57BL/6 | cathepsin B is required for optimal posttranslational processing of TNF-alpha in response to the bacterial cell wall component lipopolysacchrides | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
C57BL/6 mice | - |
| Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow | macrophages | Mus musculus | - |
| bone marrow | macrophages | Homo sapiens | - |
| macrophage | from bone marrow | Mus musculus | - |
| macrophage | from bone marrow | Homo sapiens | - |
| THP-1 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages | Mus musculus | ? | - |
? | |
| additional information | cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages | Homo sapiens | ? | - |
? | |
| additional information | cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages | Mus musculus C57BL/6 | ? | - |
? | |
| TNF-alpha + H2O | - |
Mus musculus | ? | - |
? | |
| TNF-alpha + H2O | - |
Homo sapiens | ? | - |
? | |
| TNF-alpha + H2O | cathepsin B is required for optimal posttranslational processing of TNF-alpha | Homo sapiens | ? | - |
? | |
| TNF-alpha + H2O | cathepsin B is required for optimal posttranslational processing of TNF-alpha in response to the bacterial cell wall component lipopolysacchrides | Mus musculus | ? | - |
? | |
| TNF-alpha + H2O | - |
Mus musculus C57BL/6 | ? | - |
? | |
| TNF-alpha + H2O | cathepsin B is required for optimal posttranslational processing of TNF-alpha in response to the bacterial cell wall component lipopolysacchrides | Mus musculus C57BL/6 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CTSB | - |
Mus musculus |
| CTSB | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
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