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Literature summary for 3.4.22.1 extracted from

  • Elkaim, R.; Werner, S.; Kocgozlu, L.; Tenenbaum, H.
    P. gingivalis regulates the expression of cathepsin B and cystatin C (2008), J. Dent. Res., 87, 932-936.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information Porphyromonas gingivalis strain 381 or its lipopolysaccharides increases the expression of cathepsin B 3fold in oral epithelial cells, while the expression of the cathepsin B specific inhibitor cytsatin is reduced 5fold Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cystatin C Porphyromonas gingivalis interrupts the interaction of cathepsin B with its inhibitor cystatin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Porphyromonas gingivalis strain 381 or its lipopolysaccharides increases the expression of cathepsin B in oral epithelial cells ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell oral Homo sapiens
-
gingiva
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7216
-
cathepsin B in epithelial cells Homo sapiens
7500
-
cathepsin B in epithelial cells infected with and induced by Porphyromonas gingivalis srain 381 lipopolysaccharides Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gly-Arg-7-amido-4-methylcoumarin + H2O a fluorogenic substrate Homo sapiens Gly-Arg + 7-amino-4-methylcoumarin
-
?
additional information Porphyromonas gingivalis strain 381 or its lipopolysaccharides increases the expression of cathepsin B in oral epithelial cells Homo sapiens ?
-
?