Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Porphyromonas gingivalis strain 381 or its lipopolysaccharides increases the expression of cathepsin B 3fold in oral epithelial cells, while the expression of the cathepsin B specific inhibitor cytsatin is reduced 5fold | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cystatin C | Porphyromonas gingivalis interrupts the interaction of cathepsin B with its inhibitor cystatin | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | Porphyromonas gingivalis strain 381 or its lipopolysaccharides increases the expression of cathepsin B in oral epithelial cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | oral | Homo sapiens | - |
gingiva | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
7216 | - |
cathepsin B in epithelial cells | Homo sapiens |
7500 | - |
cathepsin B in epithelial cells infected with and induced by Porphyromonas gingivalis srain 381 lipopolysaccharides | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gly-Arg-7-amido-4-methylcoumarin + H2O | a fluorogenic substrate | Homo sapiens | Gly-Arg + 7-amino-4-methylcoumarin | - |
? | |
additional information | Porphyromonas gingivalis strain 381 or its lipopolysaccharides increases the expression of cathepsin B in oral epithelial cells | Homo sapiens | ? | - |
? |