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Literature summary for 3.4.22.1 extracted from

  • Devetzi, M.; Scorilas, A.; Tsiambas, E.; Sameni, M.; Fotiou, S.; Sloane, B.F.; Talieri, M.
    Cathepsin B protein levels in endometrial cancer: Potential value as a tumour biomarker (2009), Gynecol. Oncol., 112, 531-536.
    View publication on PubMed
Search for more literature for 3.4.22.1

Application

Application Comment Organism
diagnostics increased cathepsin-B expression is predictive of more aggressive tumour behaviour over time and can be regarded as an unfavourable and independent tumour marker for endometrial cancer patients with a long follow-up Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome cathepsin B is synthesised as a pre-pro-enzyme and the primary pathways for its normal trafficking to the lysosome utilise mannose-6-phosphate receptors. Inactive pro-cathepsin-B is processed to active single and double chain forms of cathepsin-B in the late endosomes and lysosomes, respectively Homo sapiens 5768
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extracellular under certain conditions cathepsin-B may be secreted extracellularly as a pro-enzyme that requires proteolytic activation Homo sapiens
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lysosome cathepsin B is synthesised as a pre-pro-enzyme and the primary pathways for its normal trafficking to the lysosome utilise mannose-6-phosphate receptors. Inactive pro-cathepsin-B is processed to active single and double chain forms of cathepsin-B in the late endosomes and lysosomes, respectively Homo sapiens 5764
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cathepsin-B is a lysosomal cysteine proteasewith broad substrate specificity, which belongs to a family of 11 cysteine proteases. The enzyme is involved in tumor progression, e.g. of endometrial carcinomas ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification cathepsin B is synthesised as a pre-pro-enzyme and the primary pathways for its normal trafficking to the lysosome utilise mannose-6-phosphate receptors. Inactive pro-cathepsin-B is processed to active single and double chain forms of cathepsin-B in the late endosomes and lysosomes, respectively. Under certain conditions cathepsin-B may be secreted extracellularly as a pro-enzyme that requires proteolytic activation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
endometrial cancer cell line endometrial glands and epithelial cells, and also stroma Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin-B is a lysosomal cysteine proteasewith broad substrate specificity, which belongs to a family of 11 cysteine proteases. The enzyme is involved in tumor progression, e.g. of endometrial carcinomas Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
cathepsin-B
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 Homo sapiens