Protein Variants | Comment | Organism |
---|---|---|
additional information | expression of collagen IV is up-regulated in the intestine of cathepsin B-deficient mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074 | cathepsin B-specific inhibitor | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | release from intestine mucosa after mechanical injury and during initial post-traumatic stages | Mus musculus | - |
- |
lysosome | cathepsin B is an endo-lysosomal cysteine protease | Mus musculus | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Collagen IV + H2O | Mus musculus | collagen IV of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview | ? | - |
? | |
Laminin + H2O | Mus musculus | laminin of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview | ? | - |
? | |
additional information | Mus musculus | the enzyme has a principle function in gross protein degradation of internalized proteins within endo-lysosomes, but cathepsins are also involved in the processing of precursor proteins to biologically active peptides in endosomes of entero-endocrine cells. Cathepsin B, released form intestinal mucosa due to mechanical injury, plays an important role in extracellular matrix damage and the onset of postoperative ileus, an inevitable consequence of abdominal surgery, in that it contributes to disintegration of the basement membrane of the gastrointestinal tract in early post-traumatic phases. Cathepsin B is best known for its critical contribution to enhanced tumor cell invasion and metastasis, including colorectal carcinomas, by degradation of extracellular matrix components | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
enterocyte | at the basal poles of enterocytes facing the lamina propria | Mus musculus | - |
epithelial cell | - |
Mus musculus | - |
gut | - |
Mus musculus | - |
ileum | - |
Mus musculus | - |
intestine | mucosa and muscle, cathepsin B is abundantly expressed in endocytic compartments of all cells of the intestine | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Collagen IV + H2O | - |
Mus musculus | ? | - |
? | |
Collagen IV + H2O | collagen IV of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview | Mus musculus | ? | - |
? | |
Laminin + H2O | - |
Mus musculus | ? | - |
? | |
Laminin + H2O | laminin of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview | Mus musculus | ? | - |
? | |
additional information | the enzyme has a principle function in gross protein degradation of internalized proteins within endo-lysosomes, but cathepsins are also involved in the processing of precursor proteins to biologically active peptides in endosomes of entero-endocrine cells. Cathepsin B, released form intestinal mucosa due to mechanical injury, plays an important role in extracellular matrix damage and the onset of postoperative ileus, an inevitable consequence of abdominal surgery, in that it contributes to disintegration of the basement membrane of the gastrointestinal tract in early post-traumatic phases. Cathepsin B is best known for its critical contribution to enhanced tumor cell invasion and metastasis, including colorectal carcinomas, by degradation of extracellular matrix components | Mus musculus | ? | - |
? | |
N-benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin | - |
? | |
N-benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
assay at | Mus musculus |