Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Schistosome asparaginyl endopeptidase, i.e. legumain, is not essential for cathepsin B1 activation in vivo | Schistosoma mansoni |
Cloned (Comment) | Organism |
---|---|
SmCB1 expression analysis, expression in Pichia pastoris | Schistosoma mansoni |
Protein Variants | Comment | Organism |
---|---|---|
additional information | suppression of SmAE expression using RNA interference leads to an accumulation of unprocessed SmCB1 and a corresponding diminution in mature cathepsin B protein and cathepsin B enzyme activity in treated parasites | Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the protein is synthesized as a large 38 kDa precursor form which is proteolytically cleaved to yield a mature, active 31 kDa enzyme by the asparaginyl endopeptidase SmAE, i.e. schistosome legumain, SmAE is central to SmCB1 processing and activation | Schistosoma mansoni |
Synonyms | Comment | Organism |
---|---|---|
cathepsin B1 | - |
Schistosoma mansoni |
Sm31 | - |
Schistosoma mansoni |
SmCB1 | - |
Schistosoma mansoni |