Literature summary for 3.4.22.1 extracted from

Schmid, B.; Chung, D.E.; Warnecke, A.; Fichtner, I.; Kratz, F.
Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy (2007), Bioconjug. Chem., 18, 702-716.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-maleimidocaproic acid-L-Arg-Arg-Ala-Leu-Ala-Leu-Ala-camptothecin + H2O	-	Homo sapiens	?	major cleavage products are L-Leu-Ala-Leu-Ala-camptothecin, L-Ala-Leu-Ala-camptothecin, L-Leu-Ala-camptothecin, and camptothecin	?
6-maleimidocaproic acid-L-Arg-Arg-Ala-Leu-Ala-Leu-doxorubicin + H2O	-	Homo sapiens	?	major cleavage products are L-Leu-Ala-Leu-doxorubicin, L-Leu-doxorubicin, and doxorubicin	?

Synonyms

Synonyms	Comment	Organism
CatB	-	Homo sapiens

pH Stability

pH Stability	pH Stability Maximum	Comment	Organism
5	7.5	cleavage activity is more efficient at pH 5.0 than at pH 7.4	Homo sapiens

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Release 2023.1 (January 2023)