Literature summary for 3.4.22.1 extracted from

Cunha, R.L.; Urano, M.E.; Chagas, J.R.; Almeida, P.C.; Bincoletto, C.; Tersariol, I.L.; Comasseto, J.V.
Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium(IV) compounds as inhibitors of human cathepsin B (2005), Bioorg. Med. Chem. Lett., 15, 755-760.

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Application

Application	Comment	Organism
drug development	the new organotellurium(IV)compounds are powerful inhibitors of cathepsin B, constituting promising potential anti-metastatic agents	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Pichia pastoris	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(1E,4E)-1-chloro-4-ethenyl-2-(trichloro-lambda4-tellanyl)hepta-1,4,6-trien-3-ol	-	Homo sapiens
(2Z)-1,3-bis(2-methoxyphenyl)-4-(trichloro-lambda4-tellanyl)but-2-en-1-one	-	Homo sapiens
(3E)-2-bromo-3-(bromomethylidene)-2-(4-methoxyphenyl)-1-oxa-2lambda4-telluraspiro[3.5]nonane	-	Homo sapiens
(3E)-2-chloro-3-(chloromethylidene)-2-(4-methoxyphenyl)-1-oxa-2lambda4-telluraspiro[3.5]nonane	irreversible inhibition	Homo sapiens
(3E)-2-chloro-3-(chloromethylidene)-2-(4-methoxyphenyl)-1-oxa-2lambda4-telluraspiro[3.6]decane	-	Homo sapiens
(3E)-4-chloro-3-([(2Z)-4-methoxy-1-methylidenepenta-2,4-dien-1-yl](dimethyl)-lambda4-tellanyl)-2-methylbut-3-en-2-ol	-	Homo sapiens
1-(dichloro[(1Z,3E,5Z)-2-chloroocta-1,3,5,7-tetraen-1-yl]-lambda4-tellanyl)-4-methoxybenzene	-	Homo sapiens
E-64	-	Homo sapiens
N-benzyl-N,N-diethylethanaminium 2,2,2,4-tetrachloro-2,5-dihydro-2lambda6-[1,2]-oxatellurolinate complex	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P07858	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Cbz-FR-7-amido-4-methylcoumarin + H2O	37°C, pH 6.0, 200 mM NaCl, 1 mM EDTA, 5 nM DTT	Homo sapiens	Cbz-Phe-Arg + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
cathepsin B	-	Homo sapiens

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Release 2023.1 (January 2023)