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Literature summary for 3.4.22.1 extracted from
- Cathepsin B from human renal cortex (1982), Biochem. J., 205, 295-302.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | activates | Homo sapiens |  |
| EDTA | activates | Homo sapiens | |
| thiol compounds | required for full activity | Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetic acid | - |
Homo sapiens | |
| leupeptin | - |
Homo sapiens | |
| N-ethylmaleimide | - |
Homo sapiens | |
| phenylmethanesulfonyl fluoride | 18% inhibition in the presence of 10 microM | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Proteins + H2O | Homo sapiens | - |
? | - |
? | |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| dimethylsulfoxide | inhibits | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Homo sapiens | - |
| renal cortex | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzoyl-DL-Arg-beta-naphthylamide + H2O | - |
Homo sapiens | benzoyl-DL-Arg + beta-naphthylamine | - |
? | |
| benzyloxycarbonyl-Arg-Arg-beta-naphthylamide + H2O | - |
Homo sapiens | benzyloxycarbonyl-Arg-Arg + beta-naphthylamine | - |
? | |
| Proteins + H2O | - |
Homo sapiens | ? | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 4 | - |
stable for 80 min at pH 6 | Homo sapiens |
| 22 | - |
stable for 80 min at pH 6 | Homo sapiens |
| 56 | - |
90% loss of activity within 10 min | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.2 | 6.4 | - |
Homo sapiens |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 7 | stable | Homo sapiens |
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