Literature summary for 3.4.22.1 extracted from

Buttle, D.J.; Bonner, B.C.; Burnett, D.; Barrett, A.J.
A catalytically active high-Mr form of human cathepsin B from sputum (1988), Biochem. J., 254, 693-699.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cystatin	Ki: 29 nM	Homo sapiens
L-3-carboxy-2,3-trans-epoxypropionyl-leucylamido-(4-guanidino)butane	E-64	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.046	-	benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide	-	Homo sapiens
0.071	-	benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide	-	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
37000	-	gel filtration	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Proteins + H2O	Homo sapiens	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
side-chain modification	glycoprotein	Homo sapiens

Purification (Commentary)

Purification (Comment)	Organism
partially	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
sputum	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.693	-	benzyloxycarbonyl-Arg-Arg-beta-naphthylamide as substrate	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O	-	Homo sapiens	benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin	-	?
benzyloxycarbonyl-Arg-Arg-beta-naphthylamide + H2O	-	Homo sapiens	benzyloxycarbonyl-Arg-Arg + beta-naphthylamine	-	?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide	-	Homo sapiens	benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin	-	?
Proteins + H2O	-	Homo sapiens	?	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5.5	-	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000029	-	cystatin	-	Homo sapiens

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Release 2023.1 (January 2023)